Human Multi-route Exposure Assessment of Lead and Cadmium for Korean Volunteers

일부 자원자를 통한 납, 카드뮴의 다경로 인체 노출평가

  • Oh, Eun-Ha (Medical Research Center for Environmental Toxico-Genomics and Proteomics) ;
  • Lim, Ho-Sub (Medical Research Center for Environmental Toxico-Genomics and Proteomics) ;
  • Jang, Jae-Yeon (Department of Preventive Medicine, School of Medicine, Ajou University) ;
  • Lee, Eun-Il (Medical Research Center for Environmental Toxico-Genomics and Proteomics)
  • 오은하 (고려대학교 유전체 및 단백체 환경독성 의과학센터) ;
  • 임호섭 (고려대학교 유전체 및 단백체 환경독성 의과학센터) ;
  • 장재연 (아주대학교 의과대학 예방의학교실) ;
  • 이은일 (고려대학교 유전체 및 단백체 환경독성 의과학센터)
  • Published : 2006.01.31

Abstract

Objectives: We wanted to evaluate the main route of exposure to lead and cadmium for the general population in Korea by using multi-route and multi-media exposure assessment Methods: Samples of air at the homes, samples of the food and water and peripheral blood samples were collected from thirty volunteers living in Seoul (the metropolitan area), Yong-in (the suburban area) and Ansan (the industrial area) in 2001. Graphite furnace atomic absorption spectrometric methods were used for the determination of the Pb and Cd levels in the air, food, water and blood samples. Results: The average intake of lead through the air, drinking water and food were $5.06{\mu}g/day\;(26.3%)\;0.002{\mu}g/day\;(0.1%),\;and\;16.4{\mu}g/day\;(73.6%)$, respectively. The average intake of cadmium through the air, drinking water and food were $0.082{\mu}g/day\;(0.9%),\;0.001{\mu}g/day\;(0.007%),\;and\;12.61 {\mu}g/day\;(99.0%)$, respectively. The blood lead level was statistically higher in the male subjects than in the female subjects (3.39 and $2.22{\mu}g/dl$, respectively), and only gender was a significant variable on the multiple regression analysis for blood lead. Conclusions: This study showed that the intake of lead and cadmium through food was the major route of exposure. A policy to reduce the pollutants according to the exposure routes should be established. However, more studies will be needed to support these data for the general population.

Keywords

References

  1. Paustenbach DJ, Introduction: A Priemer for Conducting Human or Environmental Health Risk Assessments. In Paustenbach DJ, The Risk Assessment of Environemtal Hazards, A Wiley-Interscience Publication, New York 1989. p. 10
  2. Chung Y, Hwang MS, Yang GY, Jo S. Health risk assessment of lead exposure through multipathways in Korea. Korean Environ Toxicol 1999; 14(4): 203-216 (Korean) https://doi.org/10.1002/(SICI)1522-7278(199902)14:1<203::AID-TOX26>3.0.CO;2-X
  3. Thomas KW, Pellizzari ED, Berry M. Population-based dietary intakes and tap water concentrations for selected elements in the EPA region V national human exposure assessment survey, J Expo Anal Environ Epidemiol 1999; 9: 402-413 https://doi.org/10.1038/sj.jea.7500051
  4. 환경부. 환경오염물질의 위해성 통합평가 및 시스템 개발, 제 3권; 환경오염물질의 위해성 통합평가를 위한 다경로노출평가, 2001
  5. Park CG, Lee GJ, Yoo SJ. Distribution of lead, cadmium, zinc and copper in the field soil along the road. J Korean Soc Environ Eng 1985; 7(1): 37-42 (Korean)
  6. Hwang ID, Ki NS, Lee JH and Park IS. A study on the heavy metal concentrations and their interrelationships in woman's blood and urine in small towns. Korean Jl Prev Med 1987; 20(1): 49-55 (Korean)
  7. Chang MH, Chun JY, Kim MS. A study on the heavy metals contents in soil. Bull Environ Sci 1994; 15: 133-791 (Korean)
  8. Moon CS, Zhang ZW, Shimbo S, Watanabe T, Moon DH, Lee CS, Lee BK, Ahn KD, Lee SH, Ikeda M. Dietary intake of cadmium and lead among general population in Korea. Environ Res 1995; 71: 46-54 https://doi.org/10.1006/enrs.1995.1066
  9. Moon CS, Zhang ZW, Shimbo S, Watanabe T, Lee CU, Lee BK, Ahn KD, Lee SH, Ikeda M. Evaluation of urinary cadmium and lead as marker of background exposure of middle-aged women in Korea: Dietary intake as an influential factor. Toxicol Letter 1999; 108: 173-178 https://doi.org/10.1016/S0378-4274(99)00086-7
  10. Lee MG and Lee SR Contamination level and dietary intake of total mercury in common restaurant metals of Seoul area Korea. J Food Sci & Technol 1989; 21(2): 276-285
  11. Azar A, Snee RD, Habibi K. An epidemiologic approach to community air lead exposure using personal air samplers. Environ Qual Saf Suppl 1975;2:254-290
  12. Aschengrau A, Beiser A, Bellinger D, Copenhafer D, Weitzman M. Residential lead-based-paint hazard remediation and soil lead abatement: their impact among children with mildly elevated blood lead levels. Am J Public Health 1997; 87(10): 1698-1702 https://doi.org/10.2105/AJPH.87.10.1698
  13. Schutz A, Barregard L, Sallsten G, Wilske J, Manay N, Pereira L, Cousillas ZA Blood lead in Uruguayan children and possible sources of exposure. Environ Res 1997; 74: 17-23 https://doi.org/10.1006/enrs.1997.3742
  14. Farrely RO, Pybus J. Measurement of lead in blood and urine by atomic absorption spectrophotometer. Clin Chem 1969; 15: 566-570
  15. Ysart G, Miller P Croasdale M, Crews H, Robb P, Baxter M, de L'argy C, Harrison N. 1997 UK total diet study-dietary exposure to aluminium, arsenic, cadmium, chromium, copper, lead, mercury, nickel, selenium, tin and zinc. Food Addit Contam 2000; 17(9): 775-786 https://doi.org/10.1080/026520300415327
  16. Clayton CA, Pellizzari ED, Whitmore RW, Perritt RL, Quackenboss JJ. National human exposure assessment survey (NHEXAS): Distributions and associations of lead, arsenic and volatile organic compounds in EPA region 5. J Expo Anal Environ Epidemiol 1999; 9: 381-392 https://doi.org/10.1038/sj.jea.7500055
  17. Hoffmann K, Becker K, Friedrich C, Helm D, Krause C, Seifert B. The German environmental survey 199/1992(GerES II): Cadmium in blood urine and hair of adults and children. J Expo Anal Environ Epidemiol 2000; 1(2): 126-135
  18. Zhang ZW, Moon CS, Watanabe T, Shimbo S, He FS, Wu YQ, Zhou SF, Su DM, Qu JB, Ikeda M. Background exposure of urban populations to lead and cadmium: comparison between China and Japan. Int Arch Occup Environ Health 1997; 69: 273-281 https://doi.org/10.1007/s004200050147
  19. Park JD, Park CB, Choi BS, Kang EY, Hong YP, Chang IW, Chun BY, Yeh MH. The study on urinary cadmium concentration and renal indices of inhabitant in an abandoned mine area. Korean J Prev Med 1998; 31(3): 424-439 (Korean)
  20. Mckone TE, Daniels JI. Estimating human exposure through multiple pathways from air, water and soil. Regul Toxicol Pharmacol 1991; 13: 36-61 https://doi.org/10.1016/0273-2300(91)90040-3
  21. U.S. Environmental Protection Agency. Exposure Factors Handbooks. Office of Health and Enviommental Assessment EP A/600/889/043, March 1990
  22. Ministry of Environment Annual Report of Ambient Air Quality in Korea, 2003
  23. U.S. Environmental Protection Agency. Development of Statistical Distrbutions or Ranges of Standard Factors Used in Exposure assessments. Washington, DC: Office of Health and Environmental Assessment; 1985; EPA report No. EPA 600/8-85-010. Available from: NTIS, Springfield, VA;PB85-242667
  24. Lopez-Artiguez M, Soria ML, Camean A, Rpetto M. Cadmium in the diet of the local population of Seville(Spain). Bull Enviorn Contam Toxieol 1993; 50: 417-424
  25. Muller M and Anka M. Distribution of cadmium in the food chain(soil-plant-human)of a cadmium exposed area and the health risk of the general population. Sci Total Environ 1994; 156: 151-158 https://doi.org/10.1016/0048-9697(94)90352-2
  26. Lewis R. Metals. In LaDou J. Editor. Occupational & Environmental Medicine. 2nd ed. Prentice-Hall International, Inc., 1997. p. 412-416
  27. Barrie LA, Gregor D, Hargrave B, Lake R, Muir D, Shearer R, Tracey B, Bidlenman T. Arctic contaminants: Sources, occurrence and pathways. Sci Total Envion 1992; 122: 1-74 https://doi.org/10.1016/0048-9697(92)90245-N
  28. Thatcher RW, Lester ML, McAlaster R, Horst R. Effects of low levels of cadmium and lead on cognitive functioning in children. Arch Environ Health 1982; 37(3): 159-166 https://doi.org/10.1080/00039896.1982.10667557
  29. Lee SH, Kim HA, Park CY, Lee BK, Lee KM, Cho KS. Blood cadmium concentration in occupationaly non-exposed Korean to cadmium. Korea J Occup Health 1986; 25: 103-107 (Korean)
  30. Yocom JE. Indoor-outdoor air quality relationships-A critical review. J Air Pollu Control Assoc 1982; 32(5): 500-520 https://doi.org/10.1080/00022470.1982.10465427
  31. Fassett DW. Metals in the Environment New York, Academic Press. 1980, p61-100
  32. Mortada WI, Sobh MA, el-Defrawy MM, Farahat SE. Reference intervals of cadmium, lead, and mercury in blood, urine, and nails among residents in Mansoura city, Nile delta, Egypt Environ Res 2002; 90(2): 104-110 https://doi.org/10.1006/enrs.2002.4396
  33. Counter SA, Buchanan LH, Ortega F. Gender differences in blood lead and hemoglobin levels in Andean adults with chronic lead exposure. Int J Occup Environ Health 2001; 7(2): 113-118 https://doi.org/10.1179/oeh.2001.7.2.113
  34. Nordberg M, Winblad B, Fratiglioni L, Basun H. Lead concentrations in elderly urban people related to blood pressure and mental performance: results from a population-based study. Am J Ind Med 2000; 38(3): 290-294 https://doi.org/10.1002/1097-0274(200009)38:3<290::AID-AJIM7>3.0.CO;2-T
  35. Sanna E, Liguori A, Palmas L, Soro MR, Floris G. Blood and hair lead levels in boys and girls living in two Sardinian towns at different risks of lead pollution. Ecotoxicol Environ Saf 2003; 55(3): 293-299 https://doi.org/10.1016/S0147-6513(02)00072-6
  36. Roy A, Georgopoulos PG, Ouyang M, Freeman N, Lioy PJ. Environmental, dietary, demographic, and activity variables associated with biomarkers of exposure for benzene and lead. J Expo Anal Environ Epidemiol: 2003; 13(6): 417-426 https://doi.org/10.1038/sj.jea.7500296
  37. Morgan WD. New ways of measuring cadmium in man. Nature 1979; 282: 673-694 https://doi.org/10.1038/282673a0