The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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The effects of Pulsed Ultrasound on the bone healing process in Fracture Model of Diabetes Mellitus Rat

당뇨병증 골절렛트의 골치유 과정에서 맥동성 초음파가 미치는 영향

  • Min, Soon-Gyu (Department of Physical Therapy, College of Health and Welfare, Dongshin University) ;
  • Chun, Jin-Sung (A Physical Therapy Master, Graduate School of Health and Welfare, Dongshin University) ;
  • Yong, Jun-Hwan (Department of Occupational Therapy, Dongnam Health College) ;
  • Yoo, Young-Dae (Department of rehabilitation medicine, Wonkwang University Medical Center)
  • 민순규 (동신대학교 보건복지대학 물리치료학과) ;
  • 천진성 (동신대학교 대학원 물리치료) ;
  • 용준환 (동남보건대학 작업치료과) ;
  • 유영대 (원광대 광주한방병원)
  • Published : 2006.04.25
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Abstract

Purpose: The study to pulsed ultrasound effects of diabetes mellitus fracture model in rat. Methods: We used 36 Sprague-Dawely rats which were divided into 3 groups; the animals were divided into group of 4 rats each 4th, 14th and 28th days. All animal was induced diabetes mellitus model to used streptozotocin with 45 mg/kg. Pulsed wave were divided into $50\;mW/cm^2$ and $100\;mW/cm^2$. Results: T-ALP value was significantly change from group II, III on 14th, 28th days (p<0.05). Especially T-ALP value to between groups was significantly change from group II on 14th days (p<0.05). Osteocalcin value was significantly change from group II on 28th days(p<0.05). At fracture site, osteoblast, osteoclast expression was observed from 4th days after treatment and it reached its maximum intensity at 28th days. At fracture site, $TGF-{\beta}_1$ expression was observed from 4th days after treatment and it reached maximum intensity at 14th days. Conclusion: According to this study, diabetes mellitus fracture model to the more effective is divided into $50m\;W/cm^2$ pulsed ultrasound.

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