Effect of Job's Tear(Yul-Moo) Extracts on Mouse Spleen and $IL-1{\beta},\;IL-6,\;TNF-{\alpha}$ Cytokine Production by Peritoneal Macrophages

4주 동안의 율무 추출물 투여가 사이토카인 $IL-1{\beta},\;IL-6,\;TNF-{\alpha}$ 생성과 비장세포 증식에 미치는 영향

  • Ryu Hye-Sook (Department of Food and Nutrition, Sangji University) ;
  • Kim Hyun-Sook (Major in Food & Nutrition, Sookmyung Women's University)
  • 류혜숙 (상지대학교 이공대학 식품영양학과) ;
  • 김현숙 (숙명여자대학교 생활과학대학 식품영양학과)
  • Published : 2006.06.01

Abstract

Numerous investigators have studied various activities of natural products and have found that they have not only nutritional effects, but also beneficial properties to cure various diseases and to maintain good health. Job's Tear(Yul-Moo) is a grass crop that has long been used in traditional medicine and as a nourishing food. Although its mechanism of action remains unclear, Job's Tear has been reported to exhibit anti-inflammatory, stomachic, anti-allergic, and anti-spastic effects and has been used in China for the treatment of warts, rheumatism, and neuralgia. Previous results in our laboratory demonstrated that the ethanol extract and the water extract of Job's Tear exerted an immune regulatory function on mice cells in vitro. The present study was performed to investigate the ex vivo effect of Job's Tear on immune function. Seven to eight weeks old mice(Balb/c) were fed chow diet ad libitum and water extract of Job's Tear was administered orally every other day for four weeks at two different concentrations(50 and 500mg/kg B.W.). Splenocytes proliferation with mitogen stimulation with Con A and LPS was enhanced at 50 mg/kg B.W. of Job's Tear compared to those of the control group. The results of this ex vivo study showed that proliferation of splenocytes and macrophage activation were seen in the mice orally administrated 50 mg/kg B.W. of Job's Tear water extracts. In conclusion, this study suggests that Job's Tear extracts may enhance immune function by regulating splenocyte proliferation and the cytokine prodution capacity of activated macrophages in mice.

Keywords

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