Assessment of Thyroid Status by T4, TSH and Thyroglobulin Autoantibody in Dogs

개에서 T4, TSH, 갑상샘글로불린 자가항체 값에 의한 갑상샘의 상태 평가

  • Choi Eun-Wha (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Bae Bo-Kyoung (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Shin Il-Seob (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Bhang Dong-Ha (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Hwang Cheol-Yong (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Lee Chang-Woo (Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Seoul National University) ;
  • Youn Hwa-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University)
  • Published : 2006.06.01

Abstract

The canine thyroglobulin autoantibody assay is to be used for the diagnosis of autoimmune thyroid disease in dogs. Antithyroglobulin antibodies are present in about 50 percent of hypothyroid dogs. In this report, the sera of the five canine patients ($P1{\sim}P5$) referred to the Veterinary Medical Teaching Hospital in Seoul National University were assessed by T4, TSH and thyroglobulin autoantibody (TgAA). P1 was diagnosed as severe hypothyroidism since he showed very high TSH levels with low T4 values. P2 and P3 born with a genetic predisposition were assessed as normal in thyroid function. P4 was normal, but needed follow-up examination for TgAA assay. P5 showed the positive result in TgAA assay, so it was diagnosed as autoimmune thyroiditis. As the cases above show, not only T4 and TSH, but also TgAA assay to be considered for more accurate assessment of the status of the thyroid.

Keywords

References

  1. Andersen S, Pedersen KM, Bruun NH, Laurberg P. Narrow individual variations in serum T(4) and T(3) in normal subjects: a clue to the understanding of subclinical thyroid disease. J Clin Endocrinol Metab 2002; 87(3):1068-1072 https://doi.org/10.1210/jc.87.3.1068
  2. Beale KM, Halliwell RE, Chen CL. Prevalence of antithyroglobulin antibodies detected by enzyme-linked immunosorbent assay of canine serum. J Am Vet Med Assoc 1990; 196(5): 745-748
  3. Catharine RJ, Lynn Guptill-Yoran S. Hypothyroidism. In: Ettinger SJ and Feldman EC eds. Textbook of veterinary internal medicine, 5th ed. Philadelphia: WB Saunders Co. 2000: 1419-1429
  4. Feldman EC and Nelson RW. Hypothyroidism. In: Feldman EC and Nelson RW eds. Canine and feline endocrinology and reproduction, 2nd ed. Philadelphia: WB Saunders Co. 1996: 187-265
  5. Gosselin SJ, Capen CC, Martin SL. Histologic and ultrastructural evaluation of thyroid lesions associated with hypothyroidism in dogs. Vet Pathol 1981; 18(3): 299-309 https://doi.org/10.1177/030098588101800302
  6. Gosselin SJ, Capen CC, Martin SL, Targowski SP. Biochemical and immunological investigations on hypothyroidism in dogs. Can J Comp Med 1980; 44(2): 158-168
  7. Haines DM, Lording PM, Penhale WJ. Survey of thyroglobulin autoantibodies in dogs. Am J Vet Res 1984; 45(8): 1493-1497
  8. Nachreiner RF, Refsal KR, Graham PA, Hauptman J, Watson GL. Prevalence of autoantibodies to thyroglobulin in dogs with nonthyroidal illness. Am J Vet Res 1998; 59(8): 951-955
  9. Panciera DL. Canine Hypothyroidism. In: Torrande AG, Mooney CT eds. BSAVA manual of small animal endocrinology, 2nd ed. British small animal veterinary association. 1998: 101-113
  10. Panciera DL, Vail DM. Diseases of the thyroid glands. In: Morgan RV ed. Handbook of small animal practice, 3th ed. Philadelphia: WB Saunders Co. 1997: 447-456
  11. Patzl M, Mostl E. Determination of autoantibodies to thyroglobulin, thyroxine and triiodothyronine in canine serum. J Vet Med A Physiol Pathol Clin Med 2003; 50(2): 72-78 https://doi.org/10.1046/j.1439-0442.2003.00491.x
  12. Thacker EL, Refsal KR, Bull RW. Prevalence of autoantibodies to thyroglobulin, thyroxine, or triiodothyronine and relationship of autoantibodies and serum concentrations of iodothyronines in dogs. Am J Vet Res 1992; 53(4): 449-453