The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Kamibangpungtongsungsan on Hypertension in Spontaneous Hypertensive Rats Fed a Hyperlipidemic Diet

고cholesterol 식이 자발성 고혈압 백서(白鼠)에서의 가미방풍통성산(加味防風通聖散)이 고혈압에 미치는 영향

  • Kim, Jong-Won (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Jo, Hyun-Kyung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Yoo, Ho-Rhyong (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Seol, In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim, Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • 김종원 (대전대학교 한의과대학 내과학교실) ;
  • 조현경 (대전대학교 한의과대학 내과학교실) ;
  • 유호룡 (대전대학교 한의과대학 내과학교실) ;
  • 설인찬 (대전대학교 한의과대학 내과학교실) ;
  • 김윤식 (대전대학교 한의과대학 내과학교실)
  • Published : 2006.09.30
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Abstract

This experiment was performed to determine the effects of Kamibangpungtongsungsan on hypertension in spontaneous hypertensive rats fed a hyperlipidemic diet (H-SHR). The results are summarized as follows : 1. Kamibangpungtongsungsan significantly decreased the blood pressure and pulse of rats in H-SHR. 2. Kamibangpungtongsungsan significantly decreased the levels of Aldosterone in H-SHR. 3. Kamibangpungtongsungsan significantly decreased the levels of dopamine and epinephrine in H-SHR, but did not significantly reduce the levels of norepinephrine, in H-SHR. 4. Kamibangpungtongsungsan did not significantly reduce the levels of electrolytes in H-SHR. 5. Kamibangpungtongsungsan significantly decreased the TNF-$\alpha$ and IL-6 levels in H-SHR but the IL-10 level increase no significant. These results suggest that the Kamibangpungtongsungsan might be usefully applied for the treatment of hypertension with hyperlipidemia.

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