Studies on the Development of the Yogurt Decreasing Blood Glucose

혈당 강하 요구르트 개발에 관한 연구

  • Cho Young-Roon (Institute of Dairy Food Research, Namyang Products Co., Ltd.) ;
  • Shin Hyun-Jung (Institute of Dairy Food Research, Namyang Products Co., Ltd.) ;
  • Chang Chi-Hoon (Institute of Dairy Food Research, Namyang Products Co., Ltd.) ;
  • Nam Myoung-Soo (Department of Dairy Science, Graduate School Chungnam National University)
  • 조영훈 (남양유업 중앙연구소) ;
  • 신현정 (남양유업 중앙연구소) ;
  • 장치훈 (남양유업 중앙연구소) ;
  • 남명수 (충남대학교 농업생명과학대학 동물자원과학부)
  • Published : 2006.06.01

Abstract

This experiment was carried out to investigate the effect of hypoglycemic yogurt as a clinical test with person both who have diabetes and who don't have diabetes. Diabetes is a disease caused by unused and accumulated glucoses produced via the foods digestion due to the lack of insulin or lower tissue reaction to insulin. Patients with diabetes or complications of diabetes are on the rise annually. For the therapy and prevention of diabetes, a yogurt made from functional materials such as insulin-resistant FK-23 lactic acid bacteria, Pinitol, edible fiber which delays glucose-absorption, extract powder of glucose-absorption-inhibitory white bean and low-caloric Erythritol and banaba extract is effective for reduce or restrain the blood glucose levels. The blood glucose levels after a meal of non-diabetic persons were lower after drinking a hypoglycemic yogurt than they after drinking general yogurt. The blood glucose levels after a meal of 10 diabetic patients were checked after drinking the yoghurt. As a result, 19 mg/dL, 30 mg/dL, 31 mg/dL of blood glucose levels decreased in 30 min, 60 min and 120 min respectively after drinking the yogurt. Blood glucose inhibition rates of 80 % of the tested patients also decreased. The blood glucose level of the diabetic patients having drunk the yogurt for 30 days consistently decreased into 59 mg/dL in 120 min after a meal.

혈당 강하 요구르트의 개발을 위해 Streptococcus salivarius subsp. thermophilus와 Lactobacillus acidophilus145, bifido-bacterium infantis 혼합균주에 사균인 FK-23 유산구균, 피니톨, 식이섬유, 백강낭콩 추출 분말, 에리스리톨, 바나바 추출물 등의 기능성 성분을 포함한 요구르트를 제조하여 정상인과 혈당치가 높은 당뇨환자를 대상으로 간이 임상시험을 실시하였다. 1. 정상인의 식후 혈당치는 일반 요구르트를 섭취했을 때보다 혈당 강하 요구르트 음용 시 더 낮게 측정되었으여 임상대상자 대부분에서 동일한 현상이 나타났다. 2. 혈당치가 높은 당뇨환자 10명을 대상으로 식후 혈당치변화 및 음용기간 중 혈당치 변화를 확인한 결과 혈당 강하요구르트를 음용하기 전보다 음용 후 혈당치가 식후 30분, 식후 60분, 식후 120분 각각 19 mg/dL, 30 mg/dL, 31 mg/dL 감소하였다. 또한, 혈당 증가 억제율도 임상대상자의 80%가 감소하는 효과를 나타냈다. 3. 30일간 혈당 강하 요구르트를 음용한 후 식후 혈당치의 변화를 확인한 결과 음용전보다 음용 후 120분 경과 때, 혈당치가 59 mg/dL 감소하였으며 음용기간이 증가할수록 지속적으로 감소하는 경향을 나타내었다.

Keywords

References

  1. American Diabetes Association (1986) Nutritional recommendations and principles for individuals with diabetes mellitus. Diabetes Care 10, 126-132
  2. Ayebo, A. D., Angelo, I. A., and Shahani, K. M. (1980) Effect of ingesting Lactobacillus acidophilic milk upon fecal flora and enzyme activity in humans. Milchwissen-schaft. 35, 730-733
  3. Bailey, C. J. (1992) Hypoglycemic, antihyperglycaemic and antidiabetic drugs. Diabet Med. 9, 482-483 https://doi.org/10.1111/j.1464-5491.1992.tb01822.x
  4. Hong, H. and Maeng, W. J. (2004) Effect of malted barley extract and banaba extract on blood glucose levels in genetically diabetic mice. J. Med. Food. 7, 487-490 https://doi.org/10.1089/jmf.2004.7.487
  5. Jenkins, D. J. A., Wolever, T. M. S., and Jenkins. A. L. (1988) Starchy foods and glycemic index. Diabetes Care 10, 126-132
  6. Jenkins, D. J. A., Wolever, T. M. S., Taylor, R. H., Barker, H., and Feieiden (1981) Glycemic index of foods; a physiological basis for carbohydrate exchange. Am. J. Clin. Nutr. 34, 362-366 https://doi.org/10.1093/ajcn/34.3.362
  7. John, J. M. and Lauda, C. M. (1975) Purification and properties of phaseolamin, an inhibition of TEX>$\alpha$-amylase, from the kidney bean, Phaseolus vulgaris. J. Bio. Chem. 250, 8030-8037
  8. Kim, K. S., Sim, S. H., and Kim, P. K. (1998) Antidiabetic activity of constituents of lycii fructus. The Journal of Applied Pharmacology 6, 378-382
  9. Lee, Y. K., Lee, H. S., and Kim, B. W. (1996) Effect of short-term feeding of dietary fiber supplements on glucose metabolism in subject with non-insu1in-dependent diabetes mellitus. J. Korean Soc. Food Sci. Nutr. 25, 846-856
  10. Michel, M. D. (1987) Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy human. Mayo. Clin. Proc. 62, 249-255 https://doi.org/10.1016/S0025-6196(12)61900-4
  11. Sin, Y. C. and John, Y. J. (2003) Hypoglycemic effect of pinitol isolated from soybean. Food Science and Industry. 36, 56-60
  12. Suegara, N. K. I. (1985) Hypolipidemic effect of Streptococcus faecalis Kawai in humans and mechanisms of serum lipid reduction. Microecolagy and Therapy. 17, 271-281
  13. Watanabe, T. (1981) Studies Streptococci. 1. Destribution of fecal Streptococci in man. Microbial. Immunol. 25(3), 257-269 https://doi.org/10.1111/j.1348-0421.1981.tb00028.x
  14. Willian, V. J. (2002) Antidiabetic activity of a standardized extract from Lagerstremia speciosa leaves in Type II diabetics. Journal of Ethnopharma-cology 87, 115-117
  15. Wolever, T. M. S. (1990) Relationship between dietary fiber content and composition in foods and the glycemic index. Am. J. Clin. Nutr. 51, 72-75 https://doi.org/10.1093/ajcn/51.1.72
  16. 김용기 (1997) 당뇨병 치료에 새로운 약물의 개발. 당뇨병 21, 333-345
  17. 김유리, 이현철 (1990) 인슐린 비의존형 당뇨병의 치료에 있어서 식이섬유(Guargum)의 효과. 당뇨병 14, 73-78
  18. 노봉수, 김상용 (2000) 당알코올의 특성과 응용. 아세아문화사. 서울. pp. 61-73
  19. 라정찬, 배진희, 박형근, 김성훈. 깅경선 (2003) 당뇨환자를 위한 새로운 식이요법제에 관한 연구. 동의생리병리 학회지 17, 130-134