Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Expression of p53 and Ki-67 in Salivary Gland Tumors

타액선 종양에서 p53과 Ki-67의 발현

  • Min Hyun-Jung (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Kim Kyung-Rae (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Park Chul-Won (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Lee Hyung-Seok (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Paik Seung-Sam (Department of Pathology, College of Medicine, Hanyang University) ;
  • Oh Young-Ha (Department of Pathology, College of Medicine, Hanyang University) ;
  • Tae Kyung (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
  • 민현정 (한양대학교 의과대학 이비인후과학교실) ;
  • 김경래 (한양대학교 의과대학 이비인후과학교실) ;
  • 박철원 (한양대학교 의과대학 이비인후과학교실) ;
  • 이형석 (한양대학교 의과대학 이비인후과학교실) ;
  • 백승삼 (한양대학교 의과대학 병리학교실) ;
  • 오영하 (한양대학교 의과대학 병리학교실) ;
  • 태경 (한양대학교 의과대학 이비인후과학교실)
  • Published : 2006.05.01
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Abstract

Objectives: The p53 tumor suppressor gene has a key role in cellular control mechanisms involving apoptosis and DNA repair, leading to the G1 arrest following DNA damage. Its mutation is one of the most frequent alterations in human cancers. Ki-67 is identified in replicating cells of both benign and malignant lesions, so it can be the predictor of proliferative activity. The aim of this study is to evaluate the expression of p53 and Ki-67 in salivary gland tumors. Materials and Methods: Immunohistochemical analysis was used to detect expression of p53 and Ki-67 in paraffin-embedded samples from 31 benign and 27 malignant salivary gland tumors. Results were analyzed between benign and malignant tumors and compared with the clinical parameters such as stage and recurrence in malignant tumors. Results: p53 overexpression was detected in 19.6% of benign tumors and 40.7% of malignant tumors, but there was no statistical significance. p53 was significantly expressed in Warthin's tumor(45.5%) compared with pleomorphic adenoma(5.9%). Only 5.9% of pleomorphic adenoma were positive for p53, while 60% of carcinoma ex pleomorphic adenoma were positive for p53. Ki-67 was expressed in 3.2% of benign tumors and 51.9% of malignant tumors, which showed significant higher expression in malignant tumors. In malignant tumors, p53 and Ki-67 expressions bore no correlation to stage and recurrence. Conclusion: p53 overexpression is not associated with the progression of malignant tumors, and Ki-67 overexpression can be used as biologic indicator of malignant salivary gland tumors.

Keywords

References

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