Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지

Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Adjuvant Chemotherapy with Cisplatin plus Paclitaxel in Non-Small Cell Lung Cancer Patient

보조항암화학치료 후 발생한 항이뇨호르몬분비이상증후군

  • Baek, Yong-Soo (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Ryu, Jeong-Seon (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Hong, Seong-Bin (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Yoo, Sung-Soo (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Yu, Hyung-Kwon (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Son, Dong-Wook (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Kim, Lucia (Department of Pathology, College of Medicine, Inha University) ;
  • Kang, Hye-Sun (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Kim, Beom-Joon (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Lee, Kyung-Hee (Department of Radiology, College of Medicine, Inha University) ;
  • Cho, Jae-Hwa (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Yoon, Young-Han (Department of Chest Surgery, College of Medicine, Inha University) ;
  • Kwak, Seung-Min (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Lee, Hong-Lyeol (Department of Internal Medicine, College of Medicine, Inha University) ;
  • Kim, Kwang-Ho (Department of Chest Surgery, College of Medicine, Inha University)
  • 백용수 (인하대학교 의과대학 내과학교실) ;
  • 류정선 (인하대학교 의과대학 내과학교실) ;
  • 홍성빈 (인하대학교 의과대학 내과학교실) ;
  • 유성수 (인하대학교 의과대학 내과학교실) ;
  • 유형권 (인하대학교 의과대학 내과학교실) ;
  • 손동욱 (인하대학교 의과대학 내과학교실) ;
  • 김루시아 (인하대학교 의과대학 병리학교실) ;
  • 강혜선 (인하대학교 의과대학 내과학교실) ;
  • 김범준 (인하대학교 의과대학 내과학교실) ;
  • 이경희 (인하대학교 의과대학 진단방사선학교실) ;
  • 조재화 (인하대학교 의과대학 내과학교실) ;
  • 윤용한 (인하대학교 의과대학 흉부외과학교실) ;
  • 곽승민 (인하대학교 의과대학 내과학교실) ;
  • 이홍렬 (인하대학교 의과대학 내과학교실) ;
  • 김광호 (인하대학교 의과대학 흉부외과학교실)
  • Received : 2006.10.13
  • Accepted : 2006.12.04
  • Published : 2006.12.30
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Abstract

We report a case of pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following adjuvant chemotherapy. A 51-year-old woman with stage IIIA adenocarcinoma received left lower lobe lobectomy in July, 2006. And then combination chemotherapy with paclitaxel and cisplatin was given to the patient. In five days after completion of second cycle of the chemotherapy, she visited emergency room because of general weakness and seizure. Her brain MRI was shown to be no evidence of brain metastasis. Serum sodium, urine and plasma osmolarities were 117mEq/L, 589 and 244mOsm/kg, respectively. She was improved with fluid restriction. Although occurrence of SIADH following chemotherapy is rare, physician should give an attention the potential for development of SIADH in the course of chemotherapyin non-small cell lung cancer patient.

항이뇨호르몬분비이상증후군(이하 SIADH)은 암환자의 항암화학치료 시 드물게 관찰된다. 저자 등은 선암으로 진단받고, 좌폐하엽 절제술 시행 후 보조항암화학치료 중인 51세 여자 환자에서 발작을 동반한 SIADH 1예를 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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