Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Efficacy of Glucomannan-containing Yeast Product (Mycosorb®) and Hydrated Sodium Calcium Aluminosilicate in Preventing the Individual and Combined Toxicity of Aflatoxin and T-2 Toxin in Commercial Broilers

  • Girish, C.K. (College of Veterinary Medicine, University of Agricultural Sciences) ;
  • Devegowda, G. (College of Veterinary Medicine, University of Agricultural Sciences)
  • Received : 2005.02.22
  • Accepted : 2005.08.22
  • Published : 2006.06.01
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Abstract

A feeding trial was conducted on commercial broilers for a period of 35 days to determine the individual and combined effects of aflatoxin (AF) and T-2 toxin (T-2) on performance, organ weights and immune status. The efficacy of dietary glucomannan-containing yeast product (GYP) ($Mycosorb^{(R)}$) and hydrated sodium calcium aluminosilicate (HSCAS) in preventing the adverse effects of aflatoxin and T-2 toxin was also evaluated. Twelve dietary treatments ($4{\times}3$ factorial) comprising two dietary levels each of AF (0 and 2 mg/kg), T-2 toxin (0 and 1 mg/kg), GYP (0 and 1 kg/ton) and HSCAS (0 and 10 kg/ton) were tested on 720 commercial broiler chickens divided at random into 36 replicates of 20 chicks each (10 males and 10 females). Weight gain and feed intake were recorded weekly. Organ morphology and antibody titers for Newcastle disease (ND) and infectious bursal disease (IBD) were measured on the $35^{th}$ day. AF and T-2 toxin individually decreased weight gain and increased feed conversion ratio (FCR) (p<0.05). AF alone (p<0.05) increased weights of liver, kidney, gizzard and spleen and reduced thymus and bursal weights. T-2 toxin (p<0.05) increased liver and gizzard weights and decreased thymus weight. Both AF and T-2 toxin when fed individually affected ND and IBD titers in a significant manner. Significant interactions between AF and T-2 toxin were observed for their additive effects on weight gain, FCR, organ weights and antibody titers. Addition of GYP (p<0.05) improved weight gain, feed conversion efficiency and restored the organ weights. Antibody titers against ND and IBD were significantly improved with the supplementation of GYP. Supplementation of HSCAS (p<0.05) resulted in improvement in weight gain and restored organ weights in the groups fed AF alone, but not in T-2 toxin fed groups. HSCAS inclusion did not influence FCR in toxin fed groups. Addition of HSCAS (p<0.05) improved the antibody titers against ND and IBD only in AF fed groups. Thus, the results indicate that addition of GYP is effective in averting the individual and combined toxicity of aflatoxin and T-2 toxin in commercial broilers, while HSCAS is effective only against aflatoxin.

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References

  1. Afzal, M. and Z. Saleem. 2004. Effects of addition of a mycotoxin detoxifier in poultry feed containing different levels of aflatoxins on the performance of broilers. Asian-Aust. J. Anim. Sci. 17(7):990-994 https://doi.org/10.5713/ajas.2004.990
  2. AOAC. 1995. Official methods analysis. 16th edn. Association of official analytical chemists, Washington, DC
  3. Arvind, K. L., V. S. Patil, G. Devegowda, B. Umakantha and S. P. Ganpule. 2003. Efficacy of esterified glucomannan to counteract Mycotoxicosis in naturally contaminated feed on performance, serum biochemical and hematological parameters in broilers. Poult. Sci. 82:571-576 https://doi.org/10.1093/ps/82.4.571
  4. Atroshi, F., A. Rizzo, T. Westermarck and T. Ali-vehmas. 2002. Antioxidant nutrients and mycotoxins. Toxicology 180:151- 167 https://doi.org/10.1016/S0300-483X(02)00388-8
  5. Bailey, R. H., L. F. Kubena, R. B. Harvey, S. A. Buckley and G. E. Rottinghaus. 1998. Efficacy of various inorganic sorbents to reduce the toxicity of aflatoxin and T-2 toxin in broiler chickens. Poult. Sci. 77:1623-1630 https://doi.org/10.1093/ps/77.11.1623
  6. Barmase, B. S., G. Devegowda and U. Devurkar. 1990. Reversal of aflatoxicosis through dietary adsorbents in broiler chickens. Proc. 13th Annual Conf. Symp. Indian Poult. Sci. Assn. Bombay:20-22
  7. Bureau of Indian Standards. 1992. Nutrient requirements of Poultry. Bureau of Indian standards, Manak Bhavan, New Delhi
  8. Burmeister, H. R. 1971. T-2 Toxin production by Fusarium tricinctum on solid substrate. Appli. Micro. 21:739-742
  9. Chandrasekaran, D. 1996. Survey on the presence of T-2 and ochratoxin in feed/ingredients in Namakkal area. In: Proceedings of the 20th World's poultry congress, New Delhi, 4:268
  10. Chestnut, A. B., P. D. Anderson, M. A. Cochran, H. A. Fribourg and K. D. Twinn. 1992. Effects of Hydrated Sodium Calcium Aluminosilicate on Fescue Toxicosis and Mineral Absorption. J. Anim. Sci. 70:2838-2846 https://doi.org/10.2527/1992.7092838x
  11. Devegowda, G., B. I. R. Aravind, M. G. Morton and K. Rajendra. 1995. A biotechnological approach to counteract aflatoxicosis in broiler chickens and ducklings by the use of Saccharomyces cerevisiae. In: Proc. Feed Ingredients Asia '95, Singapore. pp. 161-171
  12. Devegowda, G., B. I. R. Arvind and M. G. Morton. 1996. Saccharomyces cerevisiae and mannanoligosaccharide to counteract aflatoxicosis in broilers. In: Proc. Aust. Poult. Sci. Symp, Sydney, Australia. 8:103-106
  13. Devegowda, G., M. V. L. N. Raju, N. Afzali and H. V. L. N. Swamy. 1998a. Mycotoxin picture worldwide: Novel solutions for their counteraction. Feed Compounder, 18(6):22-27
  14. Devegowda, G., M. V. L. N. Raju, N. Afzali and H. V. L. N. Swamy. 1998b. Mycotoxin picture worldwide: Novel solutions for their counteraction. In: Biotechnology in the Feed Industry: Proceedings of Alltech's 14th Annual Symposium (Ed. T. P. Lyons and K. A. Jacques). Nottingham University Press, Nottingham. pp. 241-255
  15. Devegowda, G. and T. N. K. Murthy. 2005. Mycotoxins: Their adverse effects in poultry and some practical solutions. In: The Mycotoxin Blue Book (Ed. D. E. Diaz). Nottingham University Press, Nottingham, UK. pp. 25-56
  16. Dvorska, J. E. and P. F. Surai. 2001. Effect of T-2 Toxin, zeolite and mycosorb on antioxidant systems of growing quail. Asian-Aust. J. Anim. Sci. 14(12):1752-1757 https://doi.org/10.5713/ajas.2001.1752
  17. Dwivedi, P. and R. B. Burns. 1984. Pathology of ochratoxicosis A in young broiler chicks. Res. Vet. Sci. 36:92-103
  18. Edrington, T. S., L. F. Kubena, R. B. Harvey and G. E. Rottinghaus. 1997. Influence of super activated charcoal on the toxic effects of aflatoxin or T-2 toxins in growing broilers. Poult. Sci. 76:1205-1211 https://doi.org/10.1093/ps/76.9.1205
  19. Harvey, R. B., L. F. Kubena, M. H. Elissalde and T. D. Philips. 1993. Efficacy of zeolite ore compounds on the toxicity of aflatoxin to growing broiler chickens. Avian diseases. 37:67-73 https://doi.org/10.2307/1591459
  20. Hoerr, F. J., W. W. Carlton and B. Yagen. 1981. Mycotoxicosis caused by a single dose of T-2 toxin or diacetoxyscirpenol in broiler chickens. Vet. Path. 18:652-664 https://doi.org/10.1177/030098588101800510
  21. Hoerr, F. J., W. W. Carlton, B. Yagen and A. Z. Joffe. 1982. Mycotoxicosis produced in broiler chickens by multiple doses of either T-2 toxin or diacetoxyscirpenol. Avian. Pathol. 11:269-383
  22. Huff, W. E., R. B. Harvey, L. F. Kubena and G. E. Rottinghaus. 1988. Toxic synergism between aflatoxin and T-2 toxin in broiler chickens. Poult. Sci. 67:1418-1423 https://doi.org/10.3382/ps.0671418
  23. Huff, W. E., L. F. Kubena, R. B. Harvey and T. D. Phillips. 1992. Efficacy of hydrated sodium calcium aluminosilicate to reduce the individual and combined toxicity of aflatoxin and ochratoxin A. Poult. Sci. 71:64-69 https://doi.org/10.3382/ps.0710064
  24. Jindal, N., S. K. Mahipal and N. K. Mahajan. 1993. The effect of hydrated sodium calcium aluminosilicate on prevention of aflatoxicosis in broilers. Indian J. Anim. Sci. 63:649-652
  25. Johri, T. S., J. Verma and A. K. Srinivastav. 1996. The individual and combined effects of aflatoxin and ochratoxin on protein quality and metabolizability of energy in broilers. Proceedings of 20th World's Poultry Congress, New Delhi, 4:275
  26. Kubena, L. F., R. B. Harvey, W. E. Huff, D. E. Corrier, T. D. Phillips and G. E. Rottinghaus. 1989. Influence of ochratoxin A and T-2 toxin singly and in combination on broiler chickens. Poult. Sci. 68:867-972 https://doi.org/10.3382/ps.0680867
  27. Kubena, L. F., R. B. Harvey, W. E. Huff, D. E. Corrier, T. D. Phillips and G. E. Rottinghaus. 1990. Efficacy of hydrated sodium calcium aluminosilicate to reduce the toxicity of aflatoxin and T-2 toxin. Poult. Sci. 69:1078-1086 https://doi.org/10.3382/ps.0691078
  28. Kubena, L. F., R. B. Harvey, S. A. Buckley, T. S. Edrington and G. E. Rottinghaus. 1997a. Individual and combined effects of moniliformin present in Fusarium fujikuroi culture material and aflatoxin in broiler chicks. Poult. Sci. 76:265-270 https://doi.org/10.1093/ps/76.2.265
  29. Kubena, L. F., T. S. Edrington, R. B. Harvey, S. A. Buckley, T. D. Phillips, G. E. Rottinghaus and H. H. Caspers. 1997b. Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and T-2 toxin or deoxynivalenol in broiler chicks. Poult. Sci. 76:1239-1247 https://doi.org/10.1093/ps/76.9.1239
  30. Kubena, L. F., R. B. Harvey, R. H. Bailey, S. A. Buckley and G. E. Rottinghaus. 1998. Effect of a hydrated sodium calcium aluminosilicate (T-bind) on mycotoxicosis in young broiler chickens. Poult. Sci. 77 (10):1502-1504 https://doi.org/10.1093/ps/77.10.1502
  31. Ledoux, D. R., G. E. Rottinghaus, A. J. Bermudez and M. Alomo Debolt. 1999. Efficacy of a hydrated sodium calcium aluminosilicate to ameliorate the toxic effects of aflatoxin in broiler chicks. Poult. Sci. 78:204-210 https://doi.org/10.1093/ps/78.2.204
  32. Lyons, T. P. 1994. In: Biotechnology in the Feed industry (Ed. T. P. Lyons and K. A. Jacques). Proceedings of the Alltech's 10th Annual symposium, Kentucky, pp. 1-48
  33. Mahesh, B. K. and G. Devegowda. 1996. Ability of Aflatoxin B1 binders to bind aflatoxin B1 in liquid media-an in vitro study. Proc. 20th World's Poultry Congress, New Delhi, 4:295-296
  34. Moshtaghian, J., C. M. Parsons, R. W. Leeper, P. C. Harrison and K. W. Koelkebeck. 1991. Effect of sodium aluminosilicate on phosphorus utilization by chicks and laying hens. Poult. Sci. 70:955-962 https://doi.org/10.3382/ps.0700955
  35. Murthy, T. N. K. and G. Devegowda. 2004. Efficacy of modified glucomannan (Mycosorb) to adsorb aflatoxin B1 in gut conditions of broiler chickens. In Proc.: 22nd World's Poultry Congress, Istanbul, Turkey. pp. 471
  36. Nelson, T. S., Z. B. Johnson, L. K. Kirby and J. N. Beasley. 1982. Digestion of dry matter and amino acids and energy utilization by chicks fed molded corn containing mycotoxins. Poult. Sci. 61:534-585
  37. Phillips, T. D., A. B. Sarr, B. A. Clement, L. F. Kubena and R. B. Harvey. 1990a. Prevention of aflatoxicosis in farm animals via selective chemisorption of aflatoxin. Pages 223-237 in: Pennington Center Nutrition Series. Vol. 1, Mycotoxins, Cancer and Health (Ed. G. A. Bray and D. H. Ryan). Louisiana State University Press, Baton Rouge, LA
  38. Phillips, T. D., B. A. Clement, L. F. Kubena and R. B. Harvey. 1990b. Detection and detoxification of aflatoxins: Prevention of aflatoxicosis and aflatoxin residues with hydrated sodium calcium aluminosilicate. Vet. Human Toxicol. 32:15-19
  39. Raju, M. V. L. N. and G. Devegowda. 2000. Influence of modified glucomannan on performance and organ morphology, serum biochemistry and hematology in broilers exposed to individual and combined mycotoxicosis (Aflatoxin, Ochratoxin and T-2 toxin). Br. Poult. Sci. 41:640-650 https://doi.org/10.1080/713654986
  40. Raju, M. V. L. N. and G. Devegowda. 2002. Esterifed glucomannan in broiler chicken diets contaminated with aflatoxin, ochratoxin and T-2 toxin: Evaluation of its binding ability (in vitro) and Efficacy as immunomodulator. Asian-Aust. J. Anim. Sci. 15:1051-1056 https://doi.org/10.5713/ajas.2002.1051
  41. Rizzi, L., A. Zaghini and P. Roncoda. 1998. Aflatoxin $B_1$ oral administrations to laying hens: Efficacy of modified mannanoligosaccharide (Mycosorb) to prevent mycotoxicosis. Enclosure Code Myco 1.5 in Biotechnology in the Feed Industry (Ed. T. P. Lyons and K. A. Jacques). Nottingham University Press, Loughborough, Leics, UK
  42. Romer, T. R., T. M. Boling and J. L. Macdonald. 1978. Gas-liquid chromatographic determination of T-2 toxin and diacetoxyscirpenol in corn and mixed feeds. J. Assoc. Off. Anal. Chem. 6:801-807
  43. Rukmini, C. and R. V. Bhatt. 1978. Occurrence of T-2 toxin in Fusarium infested sorghum from India. J. Agric. Food Chem. 26:647-649 https://doi.org/10.1021/jf60217a013
  44. Santurio, J. M., C. A. Mallmann, A. P. Rosa, G. Appel, A. Heer, S. Dageforde and M. Bottcher. 1999. Effect of sodium bentonite on the performance and blood variables of broiler chickens intoxicated with aflatoxin. Br. Poult. Sci. 40:115-119 https://doi.org/10.1080/00071669987935
  45. SAS Institute, 1996, SAS$^{\circledR}$ User's Guide: Statistics. SAS Institute Inc., Cary, NC, USA
  46. Savage, T. F., P. F. Cotter and E. I. Zakrzewska. 1996. The effect of feeding Mannanoligosaccharide on immunoglobulins, plasma IgG and bile IgA of Worldstad MW male turkeys. Poult. Sci. 75(s1):143
  47. Sengstag, C. 1997. The molecular mechanism of aflatoxin B1- induced liver cancer: is mitotic recombination involved. Molecular Carcinogenesis, 19:147-152 https://doi.org/10.1002/(SICI)1098-2744(199707)19:3<147::AID-MC1>3.0.CO;2-B
  48. Shotwell, O. L., C. W. Hesseltine, R. D. Stubblefield and W. G. Sorenson. 1966. Production of aflatoxin on rice. Appl. Microbiol. 14:425-428
  49. Smith, T. K. 1984. Spent canola oil bleaching clays: potential for treatment of T-2 toxicosis in rats and short-term inclusion in diets for immature swine. Can. J. Anim. Sci. 64:725-732 https://doi.org/10.4141/cjas84-080
  50. Swamy, H. V. L. N. and G. Devegowda. 1998. Ability of mycosorb to counteract aflatoxicosis in commercial broilers. Indian J. Poult. Sci. 33:273-278
  51. Swamy, H. V. L. N., T. K. Smith, P. F. Cotter, H. J. Boermans and A. E. Seftons. 2002. Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on prodution and metabolism in Broilers. Poult. Sci. 81:966-975 https://doi.org/10.1093/ps/81.7.966
  52. Ueno, Y. 1977. Mode of action of trichothecenes. Pure Appl. Chem., 49:1737-3745 https://doi.org/10.1351/pac197749111737
  53. Whitlow, L. W., D. E. Diaz, B. A. Hopkins and W. M. Hagler, Jr., 2000. Mycotoxins and milk safety: the potential to block transfer to milk. Pages 391-408 In: Biotechnology in the feed industry (Ed. T. P. Lyons and K. A. Jacques), Nottingham University Press, Nottingham, UK
  54. Yu, F. L. 1981. Studies on the mechanism of aflatoxin $B_1$ inhibition of rat liver nucleolar RNA synthesis. J. Biol. Chem. 256:3292-3297

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