Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
권호 표지
DOI QR코드

DOI QR Code

Recovery over Time of Production Performance and Biological Functions of Laying Hens after Withdrawal Toxic Levels of Dietary Roxarsone

  • Received : 2005.02.15
  • Accepted : 2005.09.19
  • Published : 2006.01.01
Download PDF
⟨ Previous Next ⟩

Abstract

Roxarsone (3-nitro-4-hydroxyphenylarsonic acid) has been used as feed additives in poultry industries to improve production and control coccidiosis. The effect of high dietary levels of Roxarsone (ROX) on the performance and function of internal organs and the kinetics of recovery as well as its after-effects were examined in laying hens. The inclusion rates of ROX were 0, 100, 200, 300, and 400 mg per kg feed. Inclusion up to 200 mg did not show any adverse effects (p>0.05), whereas in the 300 and 400 mg groups, significant effects, particularly in the latter, were observed for three weeks after ROX addition (p<0.05). Recovery of the physical appearance occurred soon after ROX addition was withdrawn. Recovery of performance and internal organs, however, appeared to be dependent on the amount of residual ROX in the body; as the amount of ROX decreased, the toxic effect of ROX also decreased. In the third week after the withdrawal of ROX, complete recovery was observed in the lower dosage groups (100 or 200 mg groups) (p>0.05), whereas in the higher dosage groups (300 or 400 mg groups), recovery took at least five weeks; when complete recovery was observed in egg production and in liver weight (p>0.05). On the other hand, ROX might have damaged the liver and other tissues. The recovery of liver weight was probably due to accumulation of fatty particles rather than repair. It appeared, therefore, there were little after-effects of ROX on the hen's physical appearance, but some internal organs were probably damaged.

Keywords

References

  1. Bergmeyer, H. U. 1983. Methods of Enzymatic Analysis. Vol III: Enzymes 1: Oxidoreductase, Trasferase. Verlay Chemie, Deerfield Beach, Florida. pp. 126, 416, 510
  2. Chen, K. L. and C. P. Wu. 2000. Effect of roxarsone on growth performance, liver function and leg problems of broilers. Taiwan livestock Res. 33(1):1-9
  3. Chen, K. L. and P. W. S. Chiou. 2005. Effect of restrict feeding, roxarsone or its analogues in inducing fatty livers in mule ducks. Asian-Aust. J. Anim. Sci. 18:241-248 https://doi.org/10.5713/ajas.2005.241
  4. Chen, K. L., C. P. Wu and P. W. S. Chiou. 2000. Effect of roxarsone inclusion in the diet on the performance and hepatic lipid metabolism of laying Tsaiya duck. Br. Poult. Sci. 41:363- 369 https://doi.org/10.1080/713654924
  5. Chen, K. L. and P. W. S. Chiou. 2001. Oral treatment of mule ducks with arsenicals for inducing fatty liver. Poult. Sci. 80:295-301 https://doi.org/10.1093/ps/80.3.295
  6. Chiou, P. W. S., K. L. Chen and B. Yu. 1997. Effects of roxarsone on performance, toxicity, tissue accumulation and residue of eggs and excreta in laying hens. J. Sci. Food Agric. 74:229-236 https://doi.org/10.1002/(SICI)1097-0010(199706)74:2<229::AID-JSFA793>3.0.CO;2-F
  7. Chiou, P. W. S., K. L. Chen and B. Yu. 1998. Effect of dietary organic arsenicals and cupric toxicity liver accumulation and residue in eggs and excreta of laying hens. Anim. Feed Sci. Technol. 73:161-171 https://doi.org/10.1016/S0377-8401(98)00120-5
  8. Houstmuller, A. J. 1969. In: Agarose-Gel Electrophoresis of Proteins: A Clinical Screening Test. Koninkliike VanGorcum & Co., the Netherlands. p. 5
  9. Lien, T. F., K. H. Yang and K. L. Lin. 2005. Effects of chromium propionate supplementation on growth performance, serum traits and immune response in weaned pigs. Asian-Aust. J. Anim. Sci. 18:403-408 https://doi.org/10.5713/ajas.2005.403
  10. National Research Council. 1994. The Nutrient Requirement of Poultry. National Academic of Science, Washington DC
  11. Park, S. W., H. Namkung, H. J. Ahn and I. K. Paik. 2005. Enrichment of vitamin D3, K and iron in eggs of laying hens. Asian-Aust. J. Anim. Sci. 18:226-229 https://doi.org/10.5713/ajas.2005.226
  12. SAS. 1985. SAS User's Guide, ver. 5. Cary NC, SAS Institute
  13. Schneider, W. J. 1992. Lipoprotein receptors in oocyte growth. Clin. Inv. 70:385-390
  14. Schneider, W. J. 1995. Yolk precursor transport in the laying hen. Curr. Opin. Lipidol. 6:92-96 https://doi.org/10.1097/00041433-199504000-00006
  15. Steel, R. G. D. and J. H. Torrie. 1960. Principles and procedures of statistics. McGraw-Hill. New York
  16. Wang, C. H. 1992. Plasma and tissue enzyme activities in young chickens. J. Chin. Soc. Vet. Sci. 18(3):132-138

Cited by

  1. Nitrogen-15 Determination in Tissues of Laying Hens Fed on Different Levels of $^{15}N-Chlorocholine$ Chloride ($^{15}N-CCC$) Diets vol.20, pp.3, 2006, https://doi.org/10.5713/ajas.2007.412