Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Human Acyl-CoA: Cholesterol Acyltransferase Inhibitory Effect of Flavonoids from Roots of Glycine max (L.) Merr

  • Lee, Jin-Hwan (Division of Applied Life Science (BK21 program), Department of Agricultural Chemistry, Research Institute of Life Science, Gyeongsang National University) ;
  • Seo, Woo-Duck (Division of Applied Life Science (BK21 program), Department of Agricultural Chemistry, Research Institute of Life Science, Gyeongsang National University) ;
  • Jeong, Seong-Hun (Division of Applied Life Science (BK21 program), Department of Agricultural Chemistry, Research Institute of Life Science, Gyeongsang National University) ;
  • Jeong, Tae-Sook (National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Woo-Song (National Research Laboratory of Lipid Metabolism & Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology) ;
  • Park, Ki-Hun (Division of Applied Life Science (BK21 program), Department of Agricultural Chemistry, Research Institute of Life Science, Gyeongsang National University)
  • Published : 2006.06.30
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Abstract

Isoflavones 1-3 and pterocarpans 4-8 were isolated from methanol extract of roots of Glycine max. In inhibitory effect against human acyl-CoA:cholesterol acytransferase (ACAT)-1 and ACAT-2, glyceollin I 5 showed potent hACAT-1 ($IC_{50}=299.0{\mu}M$) and hACAT-2 ($IC_{50}=82.7{\mu}M$) inhibitory activities.

Keywords

References

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