Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Effects of Jingansikpungtanggagam-bang on Central Nerve System

진간식풍탕가감방(鎭肝熄風湯加減方)이 중추신경계(中樞神經)에 미치는 효능에 관한 연구(硏究)

  • Lee, Sang-Taek (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim, Kyeong-Ok (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongshin University) ;
  • Lee, Ihn (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Jung, Yun-Gwan (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim, Geun-Woo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Koo, Byung-Soo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University)
  • 이상택 (동국대학교 한의과대학 신경정신과학교실) ;
  • 김경옥 (동신대학교 한의과대학 신경정신과학교실) ;
  • 이인 (동국대학교 한의과대학 신경정신과학교실) ;
  • 정윤관 (동국대학교 한의과대학 신경정신과학교실) ;
  • 김근우 (동국대학교 한의과대학 신경정신과학교실) ;
  • 구병수 (동국대학교 한의과대학 신경정신과학교실)
  • 발행 : 2006.12.30
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초록

This study was designed to assess Effects of jingansikpungtanggagam-bang on Central Nerve System. Method : jingansikpungtanggagam-bang, a Korean traditional prescription, was evaluated for its anticonvulsant effect, hypnotic activity, analgesic action, anxiolytic effect, memory enhancement, and MAO inhibitory activity and detennined the content of neurotransmitter in brain by HPLC method. Result : 1. The extract increased potently anticonvulsant effect at 1g/kg by 5.6-fold extention of onset time against control group. 2. The extract increased hvrmsis at 500mg/kg by over twofold length of sleeping time compared to control. 3. The extract showed a significant analgesic effect with 86.0% inhibition on writhing frequency at 500mg/kg by phenylquinone-induced writhing test. 4. The extract inhibited dose-dependently the activity of monoamine oxidase in vitro. 5. This prescription increased the brain levels of serotonin and 5-hydroxyindoleacetic acid by 3.3% and 1.4%, respectively. 6. the extract exhibited the anxiolytic effect with 21.3% decrease of the immobility duration against control group. 7. the extract enhanced memory recovery on scopolamine-induced impairment of passive avoidance performance at 1g/kg pretreatment with 20.2% increase of latency time. Conclusion : The result sugguest that jiugansikpungtanggagam-bang can be used effectively as a sedative prescription in Korean traditional medicine.

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