대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제27권2호
  • /
  • Pages.53-58
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  • 2006
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지
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[ $T_2$ ]-relaxation Time Measurement of ex vivo $^1H$ MR Metabolite Peaks for Evaluation of Human Stomach Cancer

  • Mun Chi-Woong (Department of Biomedical Engineering, Inje University) ;
  • Choi Ki-Sueng (Department of Biomedical Engineering, Inje University) ;
  • Shin Oon-Jae (Department of Radiology, Pusan Paik Hospital) ;
  • Yang Young-Ill (Department of Pathology, Inje University College of Medicine) ;
  • Chang Hee-Kyung (Department of Pathology, Kosin College of medicine) ;
  • Hu Xiaoping (Department of Biomedical Engineering, Emory University/Georgia Tech, Atlanta) ;
  • Eun Chung-Ki (Department of Diagnostic Radiology, Medical School Inje University)
  • 발행 : 2006.04.01
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초록

In this study, transverse relaxation time (T2) measurement and the evaluation of the characteristics of the spectral peak related to stomach tissue metabolites were performed using ex vivo proton magnetic resonance spectroscopic imaging (MRSI) at 1.5-T MRI/S instruments. Thirty-two gastric tissues resected from 12 patients during gastric cancer surgery, of which 19 were normal tissue and 13 were cancerous tissue, were used to measure the $T_2$ of the magnetic resonance spectroscopy (MRS) peaks. The volume of interest data results from the MRSI measurements were extracted from the proper muscle (MUS) layer and the composite mucosa/submucosa (MC/SMC) layer and were statistically analyzed. MR spectra were acquired using the chemical shift imaging (CSI) point resolved spectroscopy (CSI-PRESS) technique with the parameters of pulse repetition time (TR) and echo times (TE) TR/(TE1,TE2)=1500 msec/(35 msec, 144 msec), matrix $size=24{\times}24$, NA=1, and voxel $size=2.2{\times}2.2{\times}4mm^3$. In conclusion, the measured $T_2$ of the metabolite peaks, such as choline (3.21ppm) and lipid (1.33ppm), were significantly decreased (p<0.01 and p<0.05, respectively) in the cancerous stomach tissue.

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