The Journal of Traditional Korean Medicine (한국전통의학지)
- Volume 15 Issue 1
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- Pages.97-105
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- 2006
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- 2005-2448(pISSN)
Anti-lipid Peroxdation Effect of Ginsenoside Rd and Its Metabolite Compound K
진세노사이드 Rd와 사포닌 대사물인 compound K의 항지질과산화 효과
- Kim, Kyeng-Hyen (Department of Chemistry, Kunsan National University) ;
- Seong, Geum-Su (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
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Mun, Yeun-Ja
(Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
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Park, Si-Jun
(Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
- Shin, Mee-Ran (Dept of Prosthodontics, Hangcred Sacred Heart Hospital, Hallym University Medical Center) ;
- Chang, Che-Ghul (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
- 김경현 (군산대학교 화학과) ;
- 성금수 (원광대학교 한의학전문대학원 한약자원개발학과) ;
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문연자
(원광대학교 한의학전문대학원 한약자원개발학과) ;
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박시준
(원광대학교 한의학전문대학원 한약자원개발학과) ;
- 신미란 (한림대학교 한강성심병원 보철학과교실) ;
- 장재철 (원광대학교 한의학전문대학원 한약자원개발학과)
- Published : 2006.12.29
Abstract
To study on antioxidant effects in the liver of 40-week-old mouse, the sample were orally pretreated 5mg/kg/day for 5 days with red ginseng saponin components(total saponin, protopanaxadiol saponin, protopanaxatriol saponin, ginsenoside-Rd, ginsenoside-Re, compound-K) for 5 days. The ability of saponin to protect the mouse liver from oxidative damage was examined by determining the activity of superoxide dismutase(SOD), glutathione peroxidase(GPx) and the contents of glutathione, the level of malondialdehyde, The only protopanaxadiol among the ginseng saponin fractions was significantly increased the hepatic SOD activity(p<0.01). The red ginseng saponin induced a slight increase of GPx activity, especially ginsenoside Rd, compound K and protopanaxatriol treatments significantly increased its activity. The content of glutathione was significantly increased by total saponin, protopanaxadiol and ginsenoside Rd(p<0.01), but the oxidized glutathione level was lowered in all the red ginseng saponin. Finally, the level of malondialdehyde was significantly decreased by ginsenoside Rd and protopanaxadiol. In conclusion, protopanaxadiol and ginsenoside Rd among the saponin fraction were especially increased in the activity of hepatic antioxidative enzyme and decreased the lipid peroxidation that was expressed in term of MDA formation. This comprehensive antioxidant effects of red ginseng saponin seems to be by a certain action of saponin other than a direct antioxidant action.