Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
권호 표지

2 Year Follow-Up Study of Orbitofrontal Cortex Volume in Obsessive Compulsive Disorder

강박장애 환자에서의 안와전두피질 용적의 2년 추적 연구

  • Kim, Sung-Nyun (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul National University Hospital) ;
  • Kang, Do-Hyung (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul National University Hospital) ;
  • Yoo, So-Young (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul National University Hospital) ;
  • Roh, Kyu-Sik (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul National University Hospital) ;
  • Chang, Joon-Hwan (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul National University Hospital) ;
  • Choi, Jung-Seok (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul National University Hospital) ;
  • Ha, Tae-Hyon (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul National University Bundang Hospital) ;
  • Kwon, Jun-Soo (Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul National University Hospital)
  • 김성년 (서울대학교 의과대학 서울대학교병원 정신과학교실) ;
  • 강도형 (서울대학교 의과대학 서울대학교병원 정신과학교실) ;
  • 유소영 (서울대학교 의과대학 서울대학교병원 정신과학교실) ;
  • 노규식 (서울대학교 의과대학 서울대학교병원 정신과학교실) ;
  • 장준환 (서울대학교 의과대학 서울대학교병원 정신과학교실) ;
  • 최정석 (서울대학교 의과대학 서울대학교병원 정신과학교실) ;
  • 하태현 (분당서울대학교병원 정신과학교실) ;
  • 권준수 (서울대학교 의과대학 서울대학교병원 정신과학교실)
  • Received : 2006.10.12
  • Accepted : 2006.10.18
  • Published : 2006.10.31
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Abstract

Objective : This study was designed to examine the volumetric abnormality of orbitofrontal cortex (OFC) and its change after 2 years of pharmacotherapy in obsessive compulsive disorder (OCD) patients. Method : Volumetric magnetic resonance imaging studies were conducted in 15 OCD patients and 13 normal volunteers. For 2 years, all patients took at least one serotonin reuptake inhibitor and atypical antipsychotics were used as an augmentation therapy in most patients. The follow-up MRI studies were conducted after the pharmacotherapy and OFC volumes were measured by the manual region of interest method. Results : Bilateral OFC volumes of 15 OCD patients were significantly greater than those of the normal volunteers before the treatment. After 2 years of the treatment, significant decrease was observed in bilateral OFC volumes of OCD patients to the extent that left OFC volume of OCD patients was not different from that of the normal volunteers. Conclusion : This finding suggests that OFC is directly related to the pathophysiology of obsessive compulsive disorder.

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