Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effects of Psoralen Derivatives on hKv1.5 Current

  • Eun Jae-Soon (College of Pharmacy, Woosuk University) ;
  • Kim Dae-Keun (College of Pharmacy, Woosuk University) ;
  • Leem Jae-Yoon (College of Pharmacy, Woosuk University) ;
  • Lee Kyung-A (College of Pharmacy, Woosuk University) ;
  • Park Hoon (College of Pharmacy, Woosuk University) ;
  • Kwon Jin (Korea National College of Rehabilitation & Welfare) ;
  • Jung Young-Hoon (College of Pharmacy, SungKyunKwan University) ;
  • Kwak Yong-Geun (Department of Pharmacology, Chonbuk National University Medical School)
  • Published : 2006.06.01
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Abstract

We examined the effects of psoralen derivatives on a rapidly activating delayed rectifier $K^+$ channel (hKv1.5) cloned from human heart and stably expressed in $Ltk^-$ cells. Using the whole cell configuration of the patch-clamp technique, we found that the five psoralen derivatives inhibited hKv1.5 current. Especially, 4-(2-Propenyloxy)-7H-furo[3,2-g][1]benzopyran-7-one (compound 5) was more potent than the inhibition of the hKv1.5 current of psoralen. The compound 5 inhibited the hKv1.5 current in a concentration-, time-, and voltage-dependent manner. These results suggest that the compound 5 is an excellent candidate as an antiarrhythmic drug for atrial fibrillation.

Keywords

References

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