Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Diarylheptanoid and Flavonoid with Antioxidant Activity from Alnus japonica Steud on DPPH Free Radical Scavenging Assay

  • Han, Hae-Kyoung (College of Natural Sciences, Duksung Women's University) ;
  • Choi, Sung-Sook (College of Natural Sciences, Duksung Women's University) ;
  • Kim, Ye-Rie (College of Natural Sciences, Duksung Women's University) ;
  • Kim, Hyun-Jung (School of Life Sciences & Biotechnology, Korea University) ;
  • Kang, Gil-Myung (School of Life Sciences & Biotechnology, Korea University) ;
  • Dong, Mi-Sook (School of Life Sciences & Biotechnology, Korea University) ;
  • Na, Chun-Soo (Lifetree Biotechnology Co., Ltd) ;
  • Chung, Ha-Sook (College of Natural Sciences, Duksung Women's University)
  • Published : 2006.06.01
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Abstract

Alnus japonica Steud (Betulaceae) has long been used as a Korean traditional medicine for gastric disorders, hepatitis, and fatty liver. As a part of our study on the identification of secondary metabolites of naturally occurring bioactive compounds, we isolated 1,7-bis(4-hydroxyphenyl)-3,5-heptanediol(1), 5-hydroxy-1,7bis(4-hydroxyphenyl)-3-heptanone(2), 5,3'-dihydroxy-7,4'-dimethoxyflavone(3) and 3,5,7,3',4'-pentahydroxyflavone(4) from the dichloromethane and ethylacetate-soluble fractions of Alnus japonica Steud. These compounds showed significant antioxidant activity in a concentration-dependent manner. The $IC_{50}$ values of compounds 1, 2, 3 and 4 were 30.1, 37.4, 20.2 and 13.7 ${\mu}g/mL$, respectively, through the scavenging capacity of 1,1-diphenyl-2-picrylhydrazyl radical assay.

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