YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of 2-Substituted Flavone Derivatives

2-치환 플라본 유도체의 합성

  • Dan, On-Wha (Division of Medicinal Chemistry, College of Pharmacy, Chung-ang University) ;
  • Kim, Su-Jin (Division of Medicinal Chemistry, College of Pharmacy, Chung-ang University) ;
  • Im, Chae-Uk (Division of Medicinal Chemistry, College of Pharmacy, Chung-ang University)
  • 단온화 (중앙대학교 약학대학 의약화학 교실) ;
  • 김수진 (중앙대학교 약학대학 의약화학 교실) ;
  • 임채욱 (중앙대학교 약학대학 의약화학 교실)
  • Published : 2006.12.31
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Abstract

Flavone was found to inhibit tyrosinase and reduce synthesis of melanin to show skin-lightening effect. With the hope of identifying skin-lightening flavones, we synthesized flavone analogs. Substituted benzoic acids (1) were treated with oxalyl chloride in DMF to yield benzoyl chlorides (2), which were reacted with 2-hydroxyacetophenones (3) to afford 2-benzoyloxyacetophenones (4). These acetophenones (4) were converted into 1,3-diketones (5) with base and then treated with acid to give flavone derivatives (6).

Keywords

References

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