약학회지 (YAKHAK HOEJI)

  • 제50권6호
  • /
  • Pages.345-350
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  • 2006
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  • 0377-9556(pISSN)
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  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

db/db 마우스에서 IH-901의 항 당뇨 활성

Antidiabetic Activity of IH-901 in db/db Mice

  • 최윤숙 (경희대학교 약학대학 약물학 임상약학 교실) ;
  • 한기철 (경희대학교 약학대학 약물학 임상약학 교실) ;
  • 한은정 (경희대학교 약학대학 약물학 임상약학 교실) ;
  • 박금주 (경희대학교 약학대학 약물학 임상약학 교실) ;
  • 박종석 (경희대학교 약학대학 약물학 임상약학 교실) ;
  • 성종환 ((주) 일화 중앙연구소) ;
  • 정성현 (경희대학교 약학대학 약물학 임상약학 교실)
  • Choi, Yun-Suk (Pharmacology and Clinical Pharmacy Lab., College of Pharmacy, Kyung Hee University) ;
  • Han, Gi-Cheol (Pharmacology and Clinical Pharmacy Lab., College of Pharmacy, Kyung Hee University) ;
  • Han, Eun-Jung (Pharmacology and Clinical Pharmacy Lab., College of Pharmacy, Kyung Hee University) ;
  • Park, Keum-Joo (Pharmacology and Clinical Pharmacy Lab., College of Pharmacy, Kyung Hee University) ;
  • Park, Jong-Suk (Pharmacology and Clinical Pharmacy Lab., College of Pharmacy, Kyung Hee University) ;
  • Sung, Jong-Hwan (ILHWA Co. LTD. Central Research Center) ;
  • Chung, Sung-Hyun (Pharmacology and Clinical Pharmacy Lab., College of Pharmacy, Kyung Hee University)
  • 발행 : 2006.12.31
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초록

The pharmacological properties of ginseng are mainly attributed to ginsenosides, the active constituents that are found in the extracts of different species of ginseng. Lately; the studies on ginsenosides are mainly focused on IH-901, a major intestinal bacterial metabolite of ginsenosides. In this study; we examined the anti-diabetic activity of IH-901 in C57BU61 db/db mice model. IH-901 was administrated orally at a dose of 20 mg/kg for 5 weeks. During the experimental period, body weight and blood glucose levels were measured every week. After 5 weeks, db/db mice were sacrificed and diabetic parameters were analyzed. IH-901 treated group showed a significant decrease in fasting blood glucose levels (from 10.5 mM to 9.4 mM), insulin resistance index (from 163.6 to 100.2) and triglyceride levels (from 115.3 to 70.1) compared to the diabetic control. In Pancreatic islets morphology; IH-901 treated group revealed much less infltrated mononuclear cells, indicating that IH-901 recovered ${\beta}$-cell damage due to hyperglycemia. In addition, IH-901 upregulated expressions of glucose transporter 4 (GLUT4) and PPAR-${\gamma}$ in skeletal muscle and adipose tissue, respectively. Taken together IH-901might be a potential anti-hyperglycemic agent with insulin sensitizing effect.

키워드

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