Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory Effect of Extract of Chelidonii Harba on Sebum Synthesis

백굴채(白屈菜) 추출물의 피지생성 억제효과

  • Choi, Doo-Ho (Department of Herbal Resources, Professional Graduate School of Oriental Medicine) ;
  • Park, Si-Jun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine) ;
  • Kim, Ho-Min (Department of Herbal Resources, Professional Graduate School of Oriental Medicine) ;
  • No, Seong-Taek (Department of Herbal Resources, Professional Graduate School of Oriental Medicine) ;
  • Yoo, Il-Soo (Department of Bio & Applied Chemistry, Iksan national College) ;
  • Mun, Yeun-Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine) ;
  • Lim, Kyu-Sang (Department of Ophthalmology Otolaryngology and Dermatology, College of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine)
  • 최두호 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 박시준 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김호민 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 노성택 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 유일수 (익산대학 생명응용화학계열) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 임규상 (원광대학교 한의과대학 안이비인후피부과교실) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2006.12.25
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Abstract

Sebum is secreted due to the effect of androgen, which start to be secreted at puberty. Androgens have profound effects on the physiology of the sebaceous gland, Using the human sebocyte cell line SZ95, we investigated the inhibitory effect of Chelidonii Harba (CH) on the subum production. Our results showed that numerous cytoplasmic lipid droplets were examined by Oil red staining and lipid droplets were increased markedly by testosterone. Cell viability was dose-dependently decreased by CH as compared with untreated cells, while total lipid content and cholesterol slightly were increased by CH. Testosterone significantly stimulated the synthesis of total lipid and the synthesis of specific sebaceous lipids such as cholesterol and triglyceride. Combined treatment with CH and testosterone resulted in a lower lipid synthesis than with testosterone alone. Especially cholesteol content was reduced by combined treatment with CH and testosterone. These results indicate that CH inhibits the testosterone-induced lipid synthesis in SZ95 cells and acts antagonistically to androgen at the cellular level.

Keywords

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