Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Comparison of Immune Promotion Effects of Water-extracted Angelicae gigantis, Rehmanniae Radix, Paeoniae japonica and Polygoni multiflori Radix

보혈 약재 (補血 藥材)인 당귀, 지황, 백작약, 하수오의 면역 촉진 효과 비교 분석

  • Lee, Geum-Hong (Department of Biology, College of Natural Sciences, Kyungpook National University) ;
  • Kang, Shin-Sung (Department of Biology, College of Natural Sciences, Kyungpook National University) ;
  • An, Won-Gun (Department of Nanomedical Engineering, College of Nanoscience & Nanotechnology, Pusan National University) ;
  • Lee, Young-Sun (Department of Traditional Health Resource Development, College of Sung Duk) ;
  • Kwon, Young-Kyu (College of Oriental Medicine, Daegu Haany University) ;
  • Shin, Sang-Woo (College of Oriental Medicine, Daegu Haany University)
  • 이금홍 (경북대학교 자연과학대학 생물학과) ;
  • 강신성 (경북대학교 자연과학대학 생물학과) ;
  • 안원근 (부산대학교 나노과학기술대학 나노메디컬공학과) ;
  • 이영선 (성덕대학 전통건강자원개발과) ;
  • 권영규 (대구한의대학교 한의과대학) ;
  • 신상우 (대구한의대학교 한의과대학)
  • Published : 2006.12.25
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Abstract

Angelica gigantis (AG), Rehamaninae Radix(RR), Paenia japonica (PJ), and Polygoni multiflori Radix (PM) have been used as medicinal plants to tonify the blood. General function of the drugs have been known to nourish blood and control the heart and liver meridians. Recently, several studies have proposed mechanisms by which some oriental medicinal herbs work on the immune system. However, it is uncertain whether aqueous-extract of these drugs has immunomodulatory effect yet. In this study, I investigated the immune promotive effects of the water-extracted AG, RR, PJ and PM. The water-extracted AG, RR, PJ and PM inhibited NO production and iNOS expression in LPS stimulated RAW 264.7 macrophage cell line. Among these extracts, AG and PM induced expression of IL-2 and IFN${\gamma}$ in mouse spleen cells. In the flow cytometry analysis, PM-stimulated mouse spleen cells showed an increase in B-cell phenotype (CD45R/B220). The oral administration of Polygoni multiflori water-extracts to mice having S-180 abdominal dropsy cancer prolonged life-span more than control mice. These data suggest that among these extracts, PM has cellular and humoral immune-enhancement effect through IL-2 and IFN${\gamma}$ cytokine production, the regulation of NO production in macrophage cells and the B cell production in spleen cells.

Keywords

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