Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Nelumbo Folium and Hayopokchun-san on Diabetes Mellitus in Streptozotocin Treated Rats

하엽(荷葉) 및 하엽옥천산(荷葉玉泉散)이 streptozotocin으로 유발된 당뇨(糖尿)에 미치는 영향

  • Yang, Woong-Mo (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Chang, Mun-Seog (Department of Medicine, Division of Newborn Medicine, Children's Hospital and harvard Medical School) ;
  • Park, Wan-Su (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Byong-Hee (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Won-Nam (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, San-Woong (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Dong-Gi (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Hak-Chul (Department of Oriental Preventive Medicine, College of Oriental Medicine, Dong-Eui University) ;
  • Park, Seong-Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
  • 양웅모 (경희대학교 한의과대학 처방제형학교실) ;
  • 장문석 (하버드대학교 의과대학 소아병원) ;
  • 박완수 (경희대학교 한의과대학 처방제형학교실) ;
  • 이병희 (경희대학교 한의과대학 처방제형학교실) ;
  • 김원남 (경희대학교 한의과대학 처방제형학교실) ;
  • 김산웅 (경희대학교 한의과대학 처방제형학교실) ;
  • 최동기 (경희대학교 한의과대학 처방제형학교실) ;
  • 이학철 (동의대학교 한의과대학 예방의학교실) ;
  • 박성규 (경희대학교 한의과대학 처방제형학교실)
  • Published : 2006.12.25
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Abstract

The therapeutic anti-diabetic effect of Nelumbo Folium and a poly herbal formula (NOC) was evaluated in the streptozotocin (STZ 60 mg/kg, I.p.) induced diabetic rats. For this study, test articles were orally administrated once a day from 7 d after STZ-injection for 3 weeks. The fasting blood glucose, body weight, pancreas weight changes, oral glucose tolerance test, hemoglobin Alc (Hb A1c) level changes and the histopathological changes were observed. WNL-treated rat had lower fasting blood glucose levels compared to control group and NOC-treated rat had significantly lower fasting blood glucose levels, compared to control group (p < 0.05). After 21 days of extract treatment, body weight in control was reduced (p < 0.001). WNL and NOC groups were also reduced compared to control group but insignificantly. Pancreas weight of control group was reduced (p < 0.001), but the weight of NOC group were increased (P< 0.05). During the 2 h oral glucose tolerance test (OGTT), WNL group were improved compared to control group (P < 0.05). NOC group were improved compared to control group but insignificantly. WNL and NOC groups had lower Hb Alc level compared to control group. In addition, atrophy of islet and decrease of insulin-producing cells were detected in STZ induced diabetes rats. However, these diabetic changes were decreased in WNL and NOC groups. These results suggest that N. Folium and NOC have favorable effects to inhibit the changes on the fasting blood glucose levels, pancreas weight, glucose tolerance, hemoglobin Alc and the histopathological changes of pancreas in STZ-induced diabetes.

Keywords

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