The Journal of the Society of Stroke on Korean Medicine (대한중풍순환신경학회지)

The Society of Stroke on Korean Medicine (대한중풍순환신경학회)
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The Effects of Yanggyuksanhwa-tang Extracts on Cerebral Ischemia Following the MCA Occlusion in Rats.

흰쥐의 중대뇌동맥 결찰로 유발된 뇌허혈에서 양격산화탕(凉膈散火湯)이 신경세포에 미치는 효과

  • Shin, Gil-cho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Oh, Kyung-hwan (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Sung-hyun (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Won-chul (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 오경환 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실)
  • Published : 2006.12.01
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Abstract

Objectives : Yanggyuksanhwa-tang is a prescription used for cerebral infarction clinically. Methods : According to previous research data, the effect of Yanggyuksanhwa-tang on cerebral infarction, we induced cerebral infarction by middle cerebral artery occlusion(MCAO) in rats, and the rats were administered Yanggyuksanhwa-tang. Results: Infarct area, infarct volume were measured, and the level of elements such as c-Fos, Bax and caspase-3 in penumbra of infarct were expressed by immunohistochemical staining. Conclusion : Yanggyuksanhwa-tang showed neuroprotective effect through preventing neuronal cell apoptosis.

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Acknowledgement

이 논문은 2006학년도 동국대학교 논문게재장려금 지원으로 이루어졌음.