Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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An Association between Mitochondrial Enzyme Activity and Hearing Loss in Patients with Chronic Renal Failure

만성 신부전증 환자에서 미토콘드리아 활성과 청력손실과의 연관성

  • Kim, Eun-Sook (Vestibulocochlear Research Center & Department of Miocrobiology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, School of Medicine) ;
  • Ahn, Seon-Ho (Nephrology of Internal Medicine, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, School of Medicine) ;
  • Kim, Shin-Moo (Department of Clinical Laboratory Science, Wonkwang Health Science College) ;
  • So, Hong-Seob (Vestibulocochlear Research Center & Department of Miocrobiology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, School of Medicine) ;
  • Park, Rae-Kil (Vestibulocochlear Research Center & Department of Miocrobiology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, School of Medicine)
  • 김은숙 (원광대학교 의과대학 전정와우 연구센터) ;
  • 안선호 (원광대학교 의과대학 신장내과학교실) ;
  • 김신무 (원광보건대학 임상병리과) ;
  • 소홍섭 (원광대학교 의과대학 전정와우 연구센터) ;
  • 박래길 (원광대학교 의과대학 전정와우 연구센터)
  • Published : 2006.12.31
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Abstract

Sensorineural hearing loss is frequently found in patients with chronic renal failure (CRF). There have been many efforts to elucidate the etiologic factors of hearing loss in patients with CRF. However, there was not any clear identified cause of hearing loss. This study was undertaken to evaluate the activity of mitochondrial respiratory chain (MRC) in CRF patients with hearing impairment. To determine MRC activity, peripheral blood cells were obtained from CRF patients with hearing impairment receiving dialysis and normal subjects without any hearing problems. MRC activity of complex I and complex III was measured by the Trounces method. In MRC activities between the normal subjects group and CRF patients with hearing problems, the complex I and III activities of CRF patients with hearing problems were 63% and 85% compared with normal subjects (p<0.01). These results suggest that the activity of MRC may be implicated in the underlying mechanism of the hearing impairment in CRF patients, through mitochondrial DNA mutations at MRC complex I region with a decrement of MRC activity.

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