Childhood Kidney Diseases
- 제10권1호
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- Pages.1-7
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- 2006
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- 2384-0242(pISSN)
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- 2384-0250(eISSN)
Osteopontin과 신장 발달
Osteopontin and Developing Kidney
- Yim Hyung-Eun (Department of Pediatrics, College of Medicine, Korea University) ;
- Yoo Kee-Hwan (Department of Pediatrics, College of Medicine, Korea University)
- 발행 : 2006.04.01
초록
Osteopontin (OPN) is a glycosylated phosphoprotein which mediates cell adhesion and migration, and is produced by bone, macrophages, endothelial cells, and epithelial cells. The many regulatory functions of OPN include bone remodeling, tumor invasion, wound repair, and promotion of cell survival. It is produced by renal tubular epithelial cells, and expression is upregulated in glomerulonephritis, hypertension, ischemic acute renal failure, renal ablation, and UUO. In this review, we discuss about osteopontin in general aspect, expression, role on the development and pathologic condition of neonatal kidney.