Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Role of Protein Kinase C $\delta$ in an Early Stage of Coxsackievirus-B3-Induced Apoptosis in HeLa Cells

  • Rark Jung-Hyun (Department of Biomedical Sciences, National Institute of Health, College of Life Science, Korea University) ;
  • Cho Du-Hyong (Department of Biomedical Sciences, National Institute of Health) ;
  • Yun Cheol-Won (College of Life Science, Korea University) ;
  • Soh Jae-Won (Department of Chemistry, Inha University) ;
  • Jee Young-Mee (Department of Virology, National Institute of Health) ;
  • Park Sang-Ick (Department of Biomedical Sciences, National Institute of Health) ;
  • Jo In-Ho (Department of Biomedical Sciences, National Institute of Health) ;
  • Nam Jae-Hwan (Department of Biotechnology, The Catholic University of Korea)
  • Published : 2006.04.01
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Abstract

CVB3 is a virulent human pathogen that induces myocarditis and ultimately dilated cardiomyopathy. Although several apoptotic factors are involved in the cell death induced by CVB3, the upstream signal transduction factors of CVB3-induced apoptosis are still unclear. We explored and characterized the role of PKC $\delta$ in CVB3-infected cells. PKC $\delta$ was cleaved after CVB3 infection and was activated at 6 h postinfection. PKC $\delta$ was also translocated into the nucleus via mitochondria after CVB3 infection, and overexpression of wild-type PKC $\delta$ reduced the apoptotic cell death caused by CVB3. These results indicate that PKC $\delta$ has an antiapoptotic role in CVB3 infection.

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References

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