Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Blood-Brain Barrier Interfaces and Brain Tumors

  • Lee Sae-Won (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Stroke and neurovascular regulation laboratory) ;
  • Kim Woo-Jean (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Neuroprotection research laboratory, Massachusetts General Hospital, Harvard Medical School) ;
  • Park Jeong-Ae (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Choi Yoon-Kyung (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Kwon Yoo-Wook (Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases) ;
  • Kim Kyu-Won (Neurovascular Coordination Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)
  • Published : 2006.04.01
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Abstract

In the developing brain, capillaries are differentiated and matured into the blood-brain barrier (BBB), which is composed of cerebral endothelial cells, astrocyte end-feet, and pericytes. Since the BBB regulates the homeostasis of central nervous system (CNS), the maintenance of the BBB is important for CNS function. The disruption of the BBB may result in many brain disorders including brain tumors. However, the molecular mechanism of BBB formation and maintenance is poorly understood. Here, we summarize recent advances in the role of oxygen tension and growth factors on BBB development and maintenance, and in BBB dysfunction related with brain tumors.

Keywords

References

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