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The Pharmaceutical Society of Korea (대한약학회)
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The Inhibitory Effect and Mechanism of Luteolin 7-Glucoside on Rat Aortic Vascular Smooth Muscle Cell Proliferation

  • Kim, Tack-Joong (Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Kim, Jin-Ho (College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Jin, Yong-Ri (College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University) ;
  • Yun, Yeo-Pyo (College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University)
  • Published : 2006.01.01
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Abstract

The abnormal proliferation of aortic vascular smooth muscle cells (VSMCs) plays a central role in the pathogenesis of atherosclerosis and restenosis after angioplasty and possibly also in the development of hypertension. The present study was designed to examine the inhibitory effects and the mechanism of luteolin 7-glucoside (L7G) on the platelet-derived growth factor (PDGF)-BB-induced proliferation of VSMCs. L7G significantly inhibited the PDGF-BB-induced proliferation and the DNA synthesis of the VSMCs in a concentration-dependent manner. Pre-incubation of the VSMCs with L7G significantly inhibited the PDGF-BB-induced extracellular signal-regulated kinase 1/2 (ERK1/2), Akt and the phospholipase C $(PLC)-{\gamma}1$ activation. However, L7G had almost no affect on the phosphorylation of $PDGF-{\beta}$ receptor tyrosine kinase, which was induced by PDGF-BB. These results suggest that L7G inhibits the PDGF-BB-induced proliferation of VSMCs via the blocking of $(PLC)-{\gamma}1$, Akt, and ERK1/2 phosphorylation.

Keywords

References

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