Journal of the Optical Society of Korea

Optical Society of Korea (한국광학회)
권호 표지
DOI QR코드

DOI QR Code

Murine Heart Wall Imaging with Optical Coherence Tomography

  • Kim Jee-Hyun (Beckman Laser Institute and Medical Clinic, University of California at Irvine) ;
  • Lee Byeong-Ha (Department of Information and Communications, Gwangju Institute of Science and Technology)
  • Received : 2006.02.07
  • Published : 2006.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

M-mode imaging of the in vivo murine myocardium using optical coherence tomography (OCT) is described. Application of conventional techniques (e.g. MRI, Ultrasound imaging) for imaging the murine myocardium is problematic because the wall thickness is less than 1.5 mm (20 g mouse), and the heart rate can be as high as six hundred beats per minute. To acquire a real-time image of the murine myocardium, OCT can provide sufficient spatial resolution ($10{\mu}m$) and imaging speed (1000 A-scans/s). Strong light scattering by blood in the heart causes significant light attenuation, which makes delineation of the endocardium-chamber boundary problematic. To measure the thickness change of the myocardium during one heart beat cycle, a myocardium edge detection algorithm is developed and demonstrated.

Keywords

References

  1. D. Huang et al., 'Optical coherence tomography,' Science, vol. 254, no. 5035, pp. 1178-81, 1991 https://doi.org/10.1126/science.1957169
  2. A. M. Rollins et al., 'In vivo video rate optical coherence tomography,' Optics Express, vol. 3, no. 6, pp. 219-229, 1998 https://doi.org/10.1364/OE.3.000219
  3. M. R. Hee et al., 'Optical coherence tomography of the human retina,' Archives of Ophthalmology, vol. 113, no. 3, pp. 323-332, 1995
  4. M. G. Ducros et al., 'Polarization sensitive optical coherence tomography of the rabbit eye,' IEEE Journal of Selected Topics in Quantum Electronics, vol. 5, no. 4, pp. 1159-1167, 1999 https://doi.org/10.1109/2944.796342
  5. J. M., Schmitt, M. J. Yadlowsky, and R. F. Bonner, 'Subsurface Imaging of Living Skin with Optical Coherence Microscopy,' Dermatology, vol. 191, no. 2, pp. 93-98, 1995 https://doi.org/10.1159/000246523
  6. S. A. Boppart et al., 'Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,' Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 9, pp. 4256-4261, 1997 https://doi.org/10.1073/pnas.94.9.4256
  7. Z. P. Chen et al., 'Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography,' Optics Letters, vol. 22, no. 14, pp. 1119-1121, 1997 https://doi.org/10.1364/OL.22.001119
  8. J. G. Fujimoto et al., High resolution in vivo intraarterial imaging with optical coherence tomography,' Heart, vol. 82 no. 2, pp. 128-133, 1999 https://doi.org/10.1136/hrt.82.2.128
  9. M. E. Brezinski et al., 'Imaging of coronary artery microstructure (in vitro) with optical coherence tomography,' American Journal of Cardiology, vol. 77, no. 1, pp. 92-93, 1996 https://doi.org/10.1016/S0002-9149(97)89143-6
  10. P. Patwari et al., 'Assessment of coronary plaque with optical coherence tomography and high-frequency ultrasound,' American Journal of Cardiology, vol. 85, no. 5, pp. 641-644, 2000 https://doi.org/10.1016/S0002-9149(99)00825-5
  11. V. Twersky, 'Absorption and Multiple Scattering by Biological Suspensions,' Journal of the Optical Society of America, vol. 60, no. 8, pp. 1084-1089, 1970 https://doi.org/10.1364/JOSA.60.001084
  12. A. Roggan et al., 'Optical properties of circulating human blood in the wavelength range 400-2500 NM,' Journal of Biomedical Optics, vol. 4, no. 1, pp. 36-46, 1999 https://doi.org/10.1117/1.429919
  13. J. M. Steinke and A. P. Shepherd, 'Role of Light-Scattering in Whole-Blood Oximetry,' IEEE Transactions on Biomedical Engineering, vol. 33, no. 3, pp. 294-301, 1986 https://doi.org/10.1109/TBME.1986.325713
  14. K. Kramer et al., 'Spectrophotometric Studies on Whole Blood in the Red and near Infrared Regions,' American Journal of Physiology, vol. 159, no. 3, pp. 577-577, 1949
  15. T. Viero and Y. N., '3-D Median structures for image sequence filtering and coding,' In Motion Analysis and Image Sequence Processing, 1993
  16. S. Tsekeridou, C. K., and I. Pitas, 'Morphological Signal Adaptive Filter for Still Image and Image Sequence Filtering,' ISCAS '98, no. 4, pp. 21-24, 1998 https://doi.org/10.1109/ISCAS.1998.698742
  17. A. W. T. Lim, E. K. T., and D. P. Mital, 'Edge Detection in Range Image with Multiple Window Operators,' TENCON '92, no. 2, pp. 809-814, 1992 https://doi.org/10.1109/TENCON.1992.271858

Cited by

  1. Development of Real-time Screening System for Superior Melon Seeds Using Optical Coherence Tomography vol.22, pp.4, 2013, https://doi.org/10.5369/JSST.2013.22.4.262
  2. Optical Sensing Method for Screening Disease in Melon Seeds by Using Optical Coherence Tomography vol.11, pp.12, 2011, https://doi.org/10.3390/s111009467
  3. Optical Coherence Tomography Based on a Continuous-wave Supercontinuum Seeded by Erbium-doped Fiber's Amplified Spontaneous Emission vol.14, pp.1, 2010, https://doi.org/10.3807/JOSK.2010.14.1.049