Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Inhibition of Collagenase by Anti-inflammatory Synthetic Flavones

  • Park Hae-Il (College of Pharmacy, Kangwon National University) ;
  • Sin Bo-Young (College of Pharmacy, Kangwon National University) ;
  • Kim Hyun-Pyo (College of Pharmacy, Kangwon National University)
  • Published : 2006.03.01
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Abstract

Some flavones/flavonols were previously found to inhibit collagenase. To establish a therapeutic potential for skin inflammation, twenty-three synthetic flavone derivatives were examined for their inhibitory potential against collagenase from Clostridium histolyticum. From the results, it was found that most of them having various hydroxyl, methoxyl, methylsulfuryl and/or chloro substitution(s) on A- and B-rings were not efficient collagenase inhibitors. Among the synthetic flavones tested, only two synthetic derivatives, 3',4'-dihydroxyflavone and 5-hydroxy-4'-methoxyflavone, weakly inhibited bacterial collagenase (13-29% inhibition at 50-100 ${\mu}M$).

Keywords

References

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