Archives of Pharmacal Research

  • 제29권3호
  • /
  • Pages.195-198
  • /
  • 2006
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

New Butyrylcholinesterase Inhibitory Triterpenes from Salvia santolinifolia

  • Mehmood Sajid (Pharmaceutical Research Centre, PCSIR Laboratories Complex) ;
  • Riaz Naheed (Pharmaceutical Research Centre, PCSIR Laboratories Complex) ;
  • Nawaz Sarfraz Ahmed (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Afza Nighat (Pharmaceutical Research Centre, PCSIR Laboratories Complex) ;
  • Malik Abdul (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Choudhary Muhammad Iqbal (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi)
  • 발행 : 2006.03.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Slavins A (1) and B (2), the new amyrin type triterpenes, have been isolated from the chloroform soluble fraction of Salvia santolinifolia and assigned structures on the basis of spectral studies including 2D NMR. Both the compounds displayed inhibitory potential against the enzyme butyrylcholinesterase.

키워드

참고문헌

  1. Ali, S. I. and Nasir, Y. J., 'Flora of Pakistan,' Vol. 192, 200-202 (1990)
  2. Cheung, H. T. and Williamson D. G., NMR signals of methyl groups of triterpenes with oxygen functions at positions 2, 3 and 23. Tetrahedron, 25, 119-128 (1969) https://doi.org/10.1016/S0040-4020(01)99462-1
  3. Choudhary, M. I., Nawaz, S. A., Zaheer-ul-Haq, Lodhi, M. A., Ghayur, N., Jalil, S., Riaz, N., Yousaf, S., Malik, A., Gilani, A. H. and Atta-ur-Rahman. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Biochem. Biophys. Res. Commun., 234, 276-287 (2005)
  4. Ellman, G. L., Courtney, K. D., Andres, V. and Featherstone, R. M., A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol., 7, 88-95 (1961) https://doi.org/10.1016/0006-2952(61)90145-9
  5. Krishnamurthi, A., 'The Wealth of India,' CSIR, New Delhi, Vol. IX, 195-198 (1978)
  6. Meyer, B. N., Ferrigni, N. R., Putnam, J. E., Jacobsen, L. B., Nichols, D. E., and McLaughlin, J. L., Brine shrimp, a convenient general bioassay for active plant constituents. Planta Med., 45, 31-34 (1982) https://doi.org/10.1055/s-2007-971236
  7. Nagy, G., Dobos, A., Gunther, G., Yang, M., Blunden, G., Crabb, T. A., and Mathe I., Abietane diterpenoids from the roots of Salvia pratensis. Planta med., 64, 288-289 (1998) https://doi.org/10.1055/s-2006-957435
  8. Nawaz, H. R., Malik, A., Khan, P. M., Shujaat, S. and Atta-ur- Rehman, Novel ${\beta}-glucuronidase$ inhibiting triterpenoid from Paeonia emodi. Chem. Pharm. Bull., 48, 1771-1773 (2000) https://doi.org/10.1248/cpb.48.1771
  9. Riaz, N., Anis, I., Aziz-ur-Rehman, Malik, A., Ahmed, Z., Muhammad, P., Shujaat, S., and Atta-ur-Rahman, Emodinol, a new ${\beta}$-glucoronidase inhibiting triterpenes from Paeonia emodi. Nat. Prod. Res., 17, 247-251 (2003) https://doi.org/10.1080/1057563021000060103
  10. Riaz, N., Anis, I., Muhammad, P., Shah R., and Malik, A., Alysinol, a new triterpenes from Alysicarpus monolifer. Nat. Prod. Lett., 16, 415-418 (2002) https://doi.org/10.1080/10575630290034258
  11. Ryu, S. Y., No, Z., Kim, S. H., and Ahn J. W., Two novel abietane diterpenes from Salvia miltiorrhiza. Planta Med., 63, 44-46 (1997) https://doi.org/10.1055/s-2006-957601
  12. Ulubelen, A., Oksuz, S., Kolak U., Birman H., and Voelter W., Cardioactive terpenoids and a new rearranged diterpene from Salvia syriaca. Planta Med., 66, 627-629 (2000) https://doi.org/10.1055/s-2000-8629