Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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The Reverse Effects of Atipamezole on Medetomidine-tiletamine/zolazepam Combination Anesthesia in the Green Iguana (Iguana iguana)

그린 이구아나에서 medetomidine-tiletamine/zolazepam의 병용 마취시 atipamezole의 길항작용

  • Jung So-Young (Seoul Grand Park Zoo Veterinary Hospital Examination Affairs Division) ;
  • Kim Min-Su (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Lee Na-Young (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Kim Sun-Young (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Seo Kang-Moon (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University) ;
  • Nam Tchi-Chou (Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University)
  • Published : 2006.03.01
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Abstract

This study was performed to investigate the reverse effects of atipamezole in green iguana anesthetized with intramuscular administration of medetomidine-tiletamine/zolazepam ($Zoletil^{\circledR}$). Heart rate, respiratory rate and body temperature were measured. Anesthetic depth was evaluated by righting reflex. In all study groups, heart rate and respiratory rate significantly decreased at 5 min after anesthetic administration, and gradually increased after atipamezole administration. The present study suggested that $500{\mu}g/kg$ atipamezole was effective reversal dosage for $500{\mu}g/kg$ medetomidine and 10 mg/kg liletamine/zolazepam combination anesthesia in green iguanas.

그린 이구아나에서 medetomidine과 tiletamine/zolazepam의 병용마취시 atipamezole에 의한 길항효과를 알아 보기 위하여 본 실험을 실시하였다. 심박동수, 호흡수 그리고 체온을 측정하였으며 righting reflex에 의하여 마취의 심도 및 회복을 평가하였다. 두군 모두에서 심박동수와 호흡수는 마취주사 5분 후에 유의성 있는 감소를 보였으며 (p<0.05) atipamezole 주사 후에는 지속적으로 증가하는 양상을 보였다. 본 연구결과 atipamezole $500{\mu}g/kg$은 medetomidine $500{\mu}g/kg$과 liletamine/zolazepam 10mg/kg의 병용마취를 실시한 그린 이구아나에서 효과적인 길항 용량이라고 생각된다.

Keywords

References

  1. Barten SL. Lizard. In : Mader DM, ed. Reptile medicine and surgery, Philadelphia: W.B. Saunders. 1996: 47-60
  2. Bennett RA, Schumacher J, Hedjazi-Haring K, Newell SM. Cardiopulmonary and anesthetic effects of propofol administered intraosseously to green iguanas. J Am Vet Med Assoc 1998; 212: 93-98
  3. Cattet MR, Caulkett NA, Polischuk SC, Ramasay MA. Reversible immobilization of free-ranging polar bears with medetomidine-zolazepam-tiletamine and atipamezole. J Wild Dis 1997; 33: 611-617 https://doi.org/10.7589/0090-3558-33.3.611
  4. Chittick EJ, Stamper MA, Beasley JF, Lewbart GA, Horne WA. Medetomidine, ketamine, and sevoflurane for anesthesia of injured loggerhead sea turtles.: 13cases (1996-2000). J Am Vet Med Assoc 2002; 221: 1019-1025 https://doi.org/10.2460/javma.2002.221.1019
  5. Dennis PM, Heard DJ. Cardiopulmonary effects of a medetomidine-ketamine combin ation administered intrave-nously in gopher tortoises. J Am Vet Med Assoc 2002; 220: 1516-1519 https://doi.org/10.2460/javma.2002.220.1516
  6. Greer LL, Jenne KJ, Diggs HE. Medetomidine-ketamine anesthesia in red-eared slider turtles (Trachemys scripta elegans). Contemp Top Lab Anim Sci 2001; 40: 9-11
  7. Heaton-Jones TG, Ko JC, Heaton-Jones DL. Evaluation of medetomidine-ketamine anesthesia with atipamezole reversal in american alligators (Alligator mississippiensis). J Zoo Wildl Med 2002; 33: 36-44 https://doi.org/10.1638/1042-7260(2002)033[0036:EOMKAW]2.0.CO;2
  8. Jones DM. The sedation and anaesthesia of birds and reptiles. Vet Rec 1977; 101: 340-342 https://doi.org/10.1136/vr.101.17.340
  9. Jung SY, Kim MS, Lee NY, Kim SY, Seo KM, Nam TC. Anesthetic effects of medetomidine-tiletamine/zolazepam combination in green iguana (Iguana iguana). J Vet Clin 2005; 22: 194-197
  10. Schumacher J. Lacertilia (lizards, skins, geckos) and ampjisbaenids (worm lizards). In: Fowler ME arid Miller RE ed. Zoo and wildlife medicine, 5th Ed. Philadelphia: W.B. Saunders. 2003: 73-81
  11. Sleeman JM, Gaynor J. Sedative and cardiopulmonary effects of medetomidine and reversal with atipamezole in desert tortoises (Gopherus agassizii). J Zoo Wildl Med. 2000; 31: 28-35 https://doi.org/10.1638/1042-7260(2000)031[0028:SACEOM]2.0.CO;2
  12. Stoakes LC. Respiratory system. In: Beynon PH, ed. BSAVA Manual of reptiles, London: Br Small Anim Vet Assoc. 1992: 88-100
  13. Williams CV, Glenn KM, Levine JF, Horne WA. Comparison of the efficacy and cardio respiratory effects of medetomidine-based anesthetic protocols in ring-tailed lemurs (Lemur catta). J Zoo Wildl Med 2003: 34: 163-170 https://doi.org/10.1638/1042-7260(2003)034[0163:COTEAC]2.0.CO;2