The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)
- Volume 19 Issue 3
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- Pages.151-173
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- 2006
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- 1229-4292(pISSN)
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- 2508-3619(eISSN)
The Experimental Study on Anti-thrombotic and Anti-inflammatory Effect of BokbangHongdeungPaejangSan (BHPS)
복방홍등패장산(復方紅藤敗醬散)의 항혈전(抗血栓) 및 항염작용(抗炎作用)에 대한 실험적(實驗的) 연구(硏究)
- Lim, Dong-Ug (Dept. of Ob & Gyn, College of Oriental Medicine, Daejeon University) ;
- Yoo, Dong-Youl (Dept. of Ob & Gyn, College of Oriental Medicine, Daejeon University)
- Published : 2006.08.31
Abstract
Purpose : This study was performed to evaluate anti-thrombotic and anti-inflammatory effects of BokbangHongdeungPaejangSan water extract (BHPS). Methods : BHPS was investigated using cultured cells and a murine models. As for the parameters of inflammation, levels of several inflammatory cytokines and chemical mediators which are known to be related to inflammation were determined in mouse lung fibroblast cells (mLFC) and RAW 264.7 cells. Results : In experiment of anti-thrombotic effect, BHPS inhibited the platelet aggregation induced by ADP and epinephrine, and inhibited pulmonary embolism induced by collagen and epinephrine. BHPS increased Platelet number and fibrinogen amount, and shortened PT and APTT in thrombus model induced by dextran. In experiment of anti-inflammatory effect, BHPS inhibited IL-1