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The Pharmaceutical Society of Korea (대한약학회)
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Induction of Apoptosis and Transient Increase of Phosphorylated MAPKs by Diallyl Disulfide Treatment in Human Nasopharyngeal Carcinoma CNE2 Cells

  • Zhang, Yi Wei (Research Institute for Molecular Pharmacology and Therapeutics, Central South University) ;
  • Wen, Jun (Research Institute for Molecular Pharmacology and Therapeutics, Central South University) ;
  • Xiao, Jian Bo (School of Chemistry and Chemical Engineering, Central South University) ;
  • Talbot, Simon G. (Department of Surgery, Memorial Sloan-Kettering Cancer Center) ;
  • Li, Gloria C. (Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center) ;
  • Xu, Ming (Research Institute for Molecular Pharmacology and Therapeutics, Central South University)
  • Published : 2006.12.31
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Abstract

This study was undertaken to elucidate the effect of diallyl disulfide (DADS), an oil-soluble organosulfur compound found in garlic, in suppressing human nasopharyngeal carcinoma cells. A potent increase (of at least 9-fold) in apoptotic cells has accompanied 1) a decrease in cell viability, 2) a increase of the fraction of S-phase cells by up to 63.8%, and 3) a transient increase of the phospho-p38 and phospho-p42/44 (phosphorylated p38 MAPK and phosphorylated p42/44 MAPK) in a time-and concentration-dependent manner. These results indicate that DADS can induce apoptosis in human nasopharyngeal carcinoma cells via, at least partly, S-phase block of the cell cycle, related to a rise in MAPK phosphorylation.

Keywords

References

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