Archives of Pharmacal Research

  • 제29권12호
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  • Pages.1119-1124
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  • 2006
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Monoamine Oxidase Inhibitory Coumarins from the Aerial Parts of Dictamnus albus

  • Jeong, Seon-Hwa (College of Pharmacy, Chungbuk National University) ;
  • Han, Xiang Hua (College of Pharmacy, Chungbuk National University) ;
  • Hong, Seong-Su (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Ji-Sang (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Ji-Hye (College of Pharmacy, Chungbuk National University) ;
  • Lee, Dong-Ho (Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University) ;
  • Lee, Myung-Koo (College of Pharmacy, Chungbuk National University) ;
  • Ro,, Jai-Seup (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
  • 발행 : 2006.12.31
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초록

The methanol extract from the aerial parts of Dictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6'R-hydroxy-3', 7'-dimethyl-2'E, 7'-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds 1 and 2 inhibited MAO activity in a concentration-dependent manner with $IC_{50}$ values of 0.7 and $1.7\;{\mu}M$, respectively. Compounds 1 and 2 showed a slight and potently selective inhibitory effect against MAO-B ($IC_{50}\;0.5\;and\;0.6\;{\mu}M,\;respectively$) compared to MAO-A ($IC_{50}\;1.3\;and\;34.6\;{\mu}M,\;respectively$). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B.

키워드

참고문헌

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