Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on Anti-allergic Effects of Electroacupuncture in Allergic Mouse Model

  • Yoon Ji-Won (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University) ;
  • Jeong Kyoung-Ah (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University) ;
  • Cho Zang-Hee (Neuroscience Research Institute, Gachon Medical School) ;
  • Sung Kang-Keyng (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University)
  • Published : 2006.02.01
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Abstract

Electroacupuncture(EA) is commonly used in various diseases. In the present study, the effect of EA in the allergic mouse model was examined. Allergy is generated via immunological mechanism and non-immunological mechanism. Mast cells activated dy those mechanisms get to release various substances such as histamine, leukotrienes, prostaglandin, TNF-$\alpha$, IL-4, IL-6, etc. which induce allergic reactions and the following inflammatory responses. To evaluate the anti-allergic effects of EA, mortality, ear swelling response, vascular permeability and cytokine secretion were investigated in EA group and non-EA group of which mice were compound 48/80-induced allergy model or PCA model. Compound 48/80 induces allergic reaction via non-immunological mechanism and PCA model is generated through the same mechanism with immediate-type(Type1) allergic reaction, one of immunological allergic reactions. EA inhibited compound 48/80-induced ear swelling response but did not inhibit the systemic anaphylaxis. EA also inhibited passive cutaneous anaphylaxis(PCA) activated dy anti-dinitrophenol IgE. In addition, EA inhibited IL-6 and TNF-$\alpha$ secretion from 48 h PCA in mice. These results indicate that EA may be used for the treatment of mast cell-mediated allergic diseases, especially immediate-type(Type 1) allergy and non-immunologically mediated allergy.

Keywords

References

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