Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Genistein on Chemopreventive Activity of Human Brest Cancer

Genistein이 유방암예방 활성에 미치는 영향

  • Shon Yun-Hee (Intractable Diseases Research Center and Cardiovascular Medical Research Center and Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Kim Ho-Chang (Intractable Diseases Research Center and Cardiovascular Medical Research Center and Department of Pharmacology, College of Medicine, Dongguk University) ;
  • Nam Kyung-Soo (Intractable Diseases Research Center and Cardiovascular Medical Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
  • 손윤희 (동국대학교 난치병한양방치료연구센터, 심혈관계질환 천연물개발연구센터 및 의과대학 약리학교실) ;
  • 김호창 (동국대학교 난치병한양방치료연구센터, 심혈관계질환 천연물개발연구센터 및 의과대학 약리학교실) ;
  • 남경수 (동국대학교 난치병한양방치료연구센터, 심혈관계질환 천연물개발연구센터 및 의과대학 약리학교실)
  • Published : 2006.02.01
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Abstract

Genistein was tested for chemopreventive potential against breast cancer by measuring the effect on proliferation of human breast cancer cells, human placental aromatase activity and cyclooxygenases-2 (COX-2) expression and activity, Genistein inhibited the growth of estrogen-independent MDA-MB-231 human breast cancer cell. However, there is no inhibitory effect of genistein on human placental aromatase activity. The expression of COX-2 was inhibited by genistein in Western blot analysis. Genistein significantly inhibited COX-2 activity at the concentrations of 10 (p<0.05), 25 (p<0.05) and 50 ${\mu}M$ (p<0.01). These results suggest that genistein may have breast cancer chemopreventive potential by inhibiting the growth of human breast cancer cell and expression and activity of COX-2.

Keywords

References

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