Biomedical Science Letters (대한의생명과학회지)
- Volume 12 Issue 1
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- Pages.23-27
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- 2006
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Effect of Chlorella on Metallothionein Synthesis and Binding Capacity of Cadmium in Cadmium Poisoned Rat Liver and Kidney
- Hwang Yoo-Kyeong (Department of Biohealth Products Research Center, Inje University) ;
- Choi Hyun-Jin (Department of Biohealth Products Research Center, Inje University) ;
- Nan Meng (Department of Biohealth Products Research Center, Inje University) ;
- Yoo Jai-Du (Department of Clinical Pathology, Masan College) ;
- Kim Yong-Ho (Department of Biohealth Products Research Center, Inje University, Department of Biohealth Products Research Center, Inje University)
- Published : 2006.03.01
Abstract
The rate of metallothionein synthesis on cadmium-poisoned rats reflects the level of toxicity, and also it reduces the toxicity which is caused by the uptake of cadmium. Chlorella supplementation in the diets of the cadmium-poisoned rats decreased the concentration of cadmium in blood and urine compared with the control group. Although the liver and kidneys of rats are major target organs of cadmium and coherence of metallothionein and cadmium, no previous study has determined the correlation between the rate of metallothionein synthesis in the liver and kidneys of rats and dietary supplementation of chlorella with cadmium uptake. This study analyzed total metallothionein level on the tissue of the liver and kidneys, the concentration of cadmium bound to the metallothionein, and the total concentration of cadmium on the tissue of the liver and kidneys after dietary supplementation with 1%, 5%, and 10% dried chlorella and 40 ppm of cadmium to 46 male SD rats (mean weight: