한국해양바이오학회지 (Journal of Marine Bioscience and Biotechnology)
- 제1권3호
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- Pages.213-217
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- 2006
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- 2383-5400(eISSN)
황백의 주요 구성 화합물에 의한 약물대사효소 및 약물수송단백 저해능 평가
Inhibition of Drug-metabolizing Enzyme and Drug Transporter by Major Components of Phellodendri cortex
- 구혜영 (인제대학교 약리학교실.약물유전체연구센터) ;
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김현미
(인제대학교 약리학교실.약물유전체연구센터) ;
- 손지홍 (인제대학교 약리학교실.약물유전체연구센터) ;
- 유광현 (인제대학교 약리학교실.약물유전체연구센터)
- Ku, Hei-Young (Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine) ;
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Kim, Hyunmi
(Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine) ;
- Shon, Ji-Hong (Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine) ;
- Liu, Kwang-Hyeon (Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine)
- 발행 : 2006.09.30
초록
본 연구는 황백에 함유되어 있는 주요 화합물인 berberine, palmatine, limonin 및 rutaecarpine의 CYP2D6 및 p-glycoprotein 활성에 대한 저해정도를 탐색함으로써, 황백을 다른 양약과 병용시 약물상호작용을 유발할 수 있는 가능성을 평가하고자 하였다. 인체 간 마이크로좀 시료에 CYP2D6 동효소의 기질약물인 dextromethorphan과 NADPH 재생성계 및 저해제 (
We evaluated the potential of major components of Phellodendri cortex to inhibit the activities of CYP2D6 and p-glycoprotein. The abilities of berberine, palmatine, limonin, and rutaecarpine to inhibit CYP2D6-mediated dextromethorphan O-demethylation and calcein AM accumulation were tested using human liver microsomes and L-MDR1 cell, respectively. Berberine strongly inhibited CYP2D6 isoform activity, whereas limonin and reuaecarpine did not. The