Korean Journal of Radiology

  • 제7권3호
  • /
  • Pages.156-161
  • /
  • 2006
  • /
  • 1229-6929(pISSN)
  • /
  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지

Comparison of l.5T and 3T $^{1}H$ MR Spectroscopy for Human Brain Tumors

  • Kim, Ji-Hoon (Department of Radiology, Seoul Municipal Boramae Hospital Affiliated to Seoul National University Hospital) ;
  • Chang, Kee-Hyun (Department of Radiology, Seoul National University College of Medicine) ;
  • Na, Dong-Gyu (Department of Radiology, Seoul National University College of Medicine) ;
  • Song, In-Chan (Department of Radiology, Seoul National University College of Medicine) ;
  • Kim, Seung-Ja (Department of Radiology, Seoul National University College of Medicine) ;
  • Kwon, Bae-Ju (Department of Radiology, Seoul National University College of Medicine) ;
  • Han, Moon-Hee (Department of Radiology, Seoul National University College of Medicine)
  • 발행 : 2006.09.30
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: We wanted to estimate the practical improvements of 3T proton MR spectroscopy ($^{1}H$ MRS) as compared with 1.5T $^{1}H$ MRS for the evaluation of human brain tumors. Materials and Methods: Single voxel $^{1}H$ MRS was performed at both 1.5T and 3T in 13 patients suffering with brain tumors. Using the same data acquisition parameters at both field strengths, the $^{1}H$ MRS spectra were obtained with a short echo time (TE) (35 msec) and an intermediate TE (144 msec) with the voxel size ranging from 2.0 $cm^{3}$ to 8.7 $cm^{3}$. The signal to noise ratios (SNRs) of the metabolites (myoinositol [MI], choline compounds [Cho], creatine/phosphocreatine [Cr], N-acetyl-aspartate [NAA], lipid and lactate [LL]) and the metabolite ratios of MI/Cr, Cho/Cr, Cho/NAA and LL/Cr were compared at both TEs between the two field strengths in each brain tumor. The degrees of spectral resolution between the Cho and Cr peaks were qualitatively compared between the two field strengths in each brain tumor. Results: The SNRs of the metabolites at 3T demonstrated 49-73% increase at a short TE (p<0.01) and only 2-12% increase at an intermediate TE (p>0.05) compared with those of 1.5T. The SNR of inverted lactate at an intermediate TE decreased down to 49% with poorer inversion at 3T (p<0.05). There was no significant difference in the metabolite ratios between the two field strengths. The degrees of the spectral resolution at 3T were slightly superior to those of 1.5T at a short TE. Conclusion: As compared with 1.5T, 3T, $^{1}H$ MRS demonstrated 49-73% SNR increase in the cerebral metabolites and slightly superior spectral resolution only at a short TE, but little at an intermediate TE, in the brain tumors. There was no significant difference in the metabolite ratios between the two field strengths.

키워드

참고문헌

  1. Moller-Hartmann W, Herminghaus S, Krings T, Marquardt G, Lanfermann H, Pilatus U, et al. Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology 2002;44:371-81 https://doi.org/10.1007/s00234-001-0760-0
  2. Shimizu H, Kumabe T, Tominaga T, Kayama T, Hara K, Ono Y, et al. Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. AJNR Am J Neuroradiol 1996;17:737-747
  3. Rabinov JD, Lee PL, Barker FG, Louis DN, Harsh GR, Cosgrove GR, et al. In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience. Radiology 2002;225:871-879 https://doi.org/10.1148/radiol.2253010997
  4. Ott D, Hennig J, Ernst T. Human brain tumor: assessment with in vivo proton MR spectroscopy. Radiology 1993;186:745-752 https://doi.org/10.1148/radiology.186.3.8430183
  5. Barker PB, Glickson JD, Bryan RN. In vivo magnetic resonance spectroscopy of human brain tumors. Top Magn Reson Imaging 1993;5:32-45
  6. Gonen O, Gruber S, Li BS, Mlynarik V, Moser E. Multivoxel 3D proton spectroscopy in the brain at 1.5 versus 3.0T: signal-tonoise ratio and resolution comparison. AJNR Am J Neuroradiol 2001;22:1727-1731
  7. Barker PB, Hearshen DO, Boska MD. Single-voxel proton MRS of the human brain at 1.5T and 3.0T. Magn Reson Med 2001;45:765-769 https://doi.org/10.1002/mrm.1104
  8. Gruber S, Mlynarik V, Moser E. High-resolution 3D proton spectroscopic imaging of the human brain at 3T: SNR issues and application for anatomy-matched voxel sizes. Magn Reson Med 2003;49:299-306 https://doi.org/10.1002/mrm.10377
  9. Kantarci K, Reynolds G, Petersen RC, Boeve BF, Knopman DS, Edland SD, et al. Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3T. AJNR Am J Neuroradiol 2003;24:843-849
  10. Bartha R, Drost DJ, Menon RS, Williamson PC. Comparison of the quantification precision of human short echo time $^{1}H $spectroscopy at 1.5 and 4.0 tesla. Magn Reson Med 2000;44:185-192 https://doi.org/10.1002/1522-2594(200008)44:2<185::AID-MRM4>3.0.CO;2-V
  11. Kaminogo M, Ishimaru H, Morikawa M, Ochi M, Ushijima R, Tani M, et al. Diagnostic potential of short echo time MR spectroscopy of gliomas with single-voxel and point-resolved spatially localised proton spectroscopy of brain. Neuroradiology 2001;43:353-363 https://doi.org/10.1007/s002340000473
  12. Howe FA, Barton SJ, Cudlip SA, Stubbs M, Saunders DE, Murphy M, et al. Metabolic profiles of human brain tumors using quantitative in vivo $^{1}H $ magnetic resonance spectroscopy. Magn Reson Med 2003;49:223-232 https://doi.org/10.1002/mrm.10367
  13. Isobe T, Matsumura A, Anno I, Yoshizawa T, Nagatomo Y, Itai Y, et al. Quantification of cerebral metabolites in glioma patients with proton MR spectroscopy using T2 relaxation time correction. Magn Reson Imaging 2002;20:343-349 https://doi.org/10.1016/S0730-725X(02)00500-3