Nuclear Medicine and Molecular Imaging

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

Nuclear Medicine Imaging Diagnosis in Infectious Bone Diseases

감염성 골질환의 핵의학 영상진단

  • Choi, Yun-Young (Department of Nuclear Medicine, College of Medicine, Hanyang University)
  • 최윤영 (한양대학교 의과대학 핵의학교실)
  • Published : 2006.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Infectious and inflammatory bone diseases include a wide range of disease process, depending on the patient's age, location of infection, various causative organisms, duration from symtom onset, accompanied fracture or prior surgery, prosthesis insertion, and underlying systemic disease such as diabetes, etc. Bone infection may induce massive destruction of bones and joints, results in functional reduction and disability. The key to successful management is early diagnosis and proper treatment. Various radionuclide imaging methods including three phase bone scan, Ga-67 scan, WBC scan, and combined imaging techniques such as bone/Ga-67 scan, WBC/bone marrow scan add complementary role to the radiologic imaging modalities including plain radiography, CT and MRI. F-18 FDG PET imaging also has recently been introduced in diagnosis of infected prosthesis and chronic active osteomyelitis. Selection of proper nuclear medicine imaging method will improve the diagnostic accuracy of infections and inflammatory bone diseases, based on understading of pathogenesis and radiologic imaging findings.

Keywords

References

  1. Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004;364:369-79 https://doi.org/10.1016/S0140-6736(04)16727-5
  2. Waldvogel FA, Medoff G, Swartz MN. Osteomyelitis: A review of clinical features, therapeutic considerations and unusual aspects. Part 3. Osteomyelitis associated wih vascular insufficiency[Review]. N Engl J Med 1970;282:316-22 https://doi.org/10.1056/NEJM197002052820606
  3. Lee SH, Hur CY, Chang JS, Song HY, Moon JY. A clinical study upon acute osteomyelitis and pyogenic arthritis. J Kor Orthop Assoc 1991;26:1891-7
  4. Rogers LF, Norris MA. Infection and inflammations of bones, In: Juhl JH, Crummy AB, Kuhlman JE, editors. Essentials of radiologic imaging. 7th ed. Philadelphia: Lippincott Williams & Wilkins;1998. p. 173-98
  5. Concia E, Prandini N, Massari L et al. Osteomyelitis: clinical update for practial guidelines. Nuc Med Comm 2006;27:645-60 https://doi.org/10.1097/00006231-200608000-00007
  6. Pradini N, Lazzeri E, Rossi B, Erba P, Parisella MG, Signore A. Nuclear medicine imaging of bone infection. Nuc Med Comm 2006;27:633-44 https://doi.org/10.1097/00006231-200608000-00006
  7. Love C, Tomas MB, Tronco GG, Palestro CF. FDG PET of infection and inflammation. Radiographics 2005;25:1357-68 https://doi.org/10.1148/rg.255045122
  8. Zhuang H, Yang H, Alavi A. Critical role of F-18 labeled fluorodeoxyglucose PET in the management of patients with arthroplasty. PET Clin 2006;1:99-106 https://doi.org/10.1016/j.cpet.2006.01.001
  9. Meller J. Sahlmann CO, Liersch T. Tang PH, Alavi A. Nonprosthesis orthopedic applications of F-18 Fluoro-2-Deoxy-d-Gucose PET in the detection of osteomyelitis. PET Clin 2006;1:107-21 https://doi.org/10.1016/j.cpet.2006.01.004
  10. Lee SM, Bae SK, Cho MR. Acute osteomyelitis shown as a cold lesion on bone scan. Kor J Nucl Med 2000;34:516-20
  11. Pennington WT, Mott MP, Thometz JG, Sty JR, Metz D. Photopenic bone scan osteomyelitis: a clinical perspective. J Pediatr Orthop 1999;19:695-8 https://doi.org/10.1097/00004694-199911000-00001
  12. Elgazzar AH. Orthopedic nuclear medicine. New York: Springer-Verlag;2004. p.33-71
  13. Tumeh SS, Aliabadi P, Weissman BN et al. Chronic osteomyelitis: bone and gallium scan patterns associated with active disease. Radiology 1986;158:685-8 https://doi.org/10.1148/radiology.158.3.3945738
  14. Reinartz P, Mumme T, Hermanns B et al. Radionuclide imaging of painful hip arthroplasty. J Bone Joint Surg Br 2005;87:465-70 https://doi.org/10.1302/0301-620X.87B4.14954
  15. Hochhold J, Yang H, Zhuang H, Alavi A. Application of F-18 Fluorodeoxyglucose and PET in evaluation of the diabetic foot. PET Clin 2006;1:123-30 https://doi.org/10.1016/j.cpet.2006.03.001