Nuclear Medicine and Molecular Imaging

The Korean Society of Nuclear Medicine (대한핵의학회)
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Transient Diffuse Hepatic Uptake of $^{99m}Tc$-MDP after Hepatitis B Vaccination

B형 간염 백신 접종 후 일시적으로 관찰된 $^{99m}Tc$-MDP의 미만성 간 섭취

  • Kim, Hyun-Jin (Departments of Radiology, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Park, Young-Ha (Departments of Radiology, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Hwang, Seong-Su (Departments of Radiology, St. Vincent's Hospital, The Catholic University of Korea) ;
  • Kim, Sang-Heum (Department of Radiology, Eulji Hospital, Eulji University) ;
  • Chung, Soo-Kyo (Departments of Radiology, Kangnam St. Mary's Hospital, The Catholic University of Korea)
  • 김현진 (가톨릭대학교 성빈센트병원 영상의학과) ;
  • 박영하 (가톨릭대학교 성빈센트병원 영상의학과) ;
  • 황성수 (가톨릭대학교 성빈센트병원 영상의학과) ;
  • 김상흠 (을지대학교 을지병원 영상의학과) ;
  • 정수교 (가톨릭대학교 강남성모병원 영상의학과)
  • Published : 2006.02.28
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Abstract

A 38-year-old female with arthralgia in right elbow joint for 6 months was referred for a bone scan which showed diffuse uptakes of $^{99m}Tc$-MDP in the liver and spleen without hepatosplenomegaly. She had a history of hepatitis B vaccination 3 days ago. These uptakes were disappeared on the follow-up bone scan after 4 months. We suggest this transient diffuse hepatic uptake after vaccination of hepatitis B might be due to aluminum component within the hepatitis B vaccine as adjuvant.

Keywords

References

  1. Poulose KP, Reba RC, Eckelman WC. Extraosseous localization of $^{99m}Tc$-Sn pyrophosphate. Br J Radiol 1975;48:724-6 https://doi.org/10.1259/0007-1285-48-573-724
  2. Hansen S, Stadalnik RC. Liver uptake of Tc-99m pyrophosphate. Semin Nucl Med 1982;12:89-91
  3. MacDonald J. Idiopathic hepatic uptake of (99m)Tc methylene diphosphonate: a case report. J Nucl Med Technol 2001;29:32-6
  4. Crawford JA, Gumerman Lw. Alteration of body distribution of $^{99m}Tc$-pyrophosphate by radiographic contrast. Clin Nucl Med 1978;3:305-7 https://doi.org/10.1097/00003072-197808000-00001
  5. Rao BK, Padmalatha C, Au Buchon J, Lieberman LM. Hepatic and splenic scintigraphy in idiopathic systemic amyloidosis. Eur J Nucl Med 1981;6:143-6 https://doi.org/10.1007/BF00253162
  6. Bykov S, Garty I, Bisharat N. Transient Tc-99m MDP hepatic uptake induced by acute hypoxic hepatitis. Clin Nucl Med 2001;26:550-1 https://doi.org/10.1097/00003072-200106000-00018
  7. Hosono M, Machida K, Honda N, Takahashi T, Ohtawa N. Visualization of fatal hepatic necrosis on bone scan. Clin Nucl Med 2003;28:398-9 https://doi.org/10.1097/00003072-200305000-00007
  8. Chaudhuri TK. Liver uptake of $^{99m}Tc$-diphosphomate. Radiology 1978;119:485-6
  9. Zimmer AM, Pavel DG. Experimental investigations of the possible cause of liver appearance during bone scanning. Radiology 1978;128:813-8
  10. Dudczak R, Angelberger P, Kletter K, et al. Transient accumulation of Tc-99m MDP in the liver. Eur J Nucl Med 1980;5:189-91 https://doi.org/10.1007/BF00252484
  11. Park CH, Kim HS, Shin HY, Kim HC. Hepatic uptake of Tc-99m MDP on bone scintigraphy from intravenous iron therapy (Blutal). Clin Nucl Med 1997;22:762-4 https://doi.org/10.1097/00003072-199711000-00006
  12. Tuncel M, Erbas B, Mahmoudian B. Gamut: Soft tissue uptake of bone radiopharmaceuticals. Semin Nucl Med 2003;33:334-7 https://doi.org/10.1016/S0001-2998(03)00037-0
  13. Hardy JG, Anderson GS, Newble GM. Uptake of $^{99m}Tc$-pyrophophate by metastatic extragenital seminoma. J Nucl Med 1976;17:1105-6
  14. Bom H-S, Park S-G, Chung J-K, Lee M-C, Cho B-Y, Koh C-S. Study on the soft tissue uptake of $^{99m}Tc$-methylene diphophate. Korean J Nucl Med 1986;20:17-23
  15. The Korean Pediatric Society. Immunization Practice of The Korean Pediatric Society 4th ed. Seoul; Medicine Publishing 1997;71-91