Brain-Derived Neurotrophic Factor(BDNF) Genetic Polymorphism and the Long-term Outcome of Antidepressant Treatment in Korean Depressive Patients

한국인 우울 장애 환자에서 Brain-Derived Neurotrophic Factor(BDNF)의 유전자 다형성과 항우울제의 장기 치료 반응

  • Koo, Jae-Woo (Department of Psychiatry, Depression Center and Pharmacogenomic Research Center for Psychotropic Drugs, College off Medicine, Korea University, Anam Hospital) ;
  • Lee, Hwa-Young (Department of Psychiatry, Korea University College off Medicine, Ansan Hospital) ;
  • Paik, Jong-Woo (Department of Psychiatry, Depression Center and Pharmacogenomic Research Center for Psychotropic Drugs, College off Medicine, Korea University, Anam Hospital) ;
  • Kang, Rhee-Hun (Department of Psychiatry, Depression Center and Pharmacogenomic Research Center for Psychotropic Drugs, College off Medicine, Korea University, Anam Hospital) ;
  • Lee, Min-Soo (Department of Psychiatry, Depression Center and Pharmacogenomic Research Center for Psychotropic Drugs, College off Medicine, Korea University, Anam Hospital)
  • 구재우 (고려대학교 의과대학 안암병원 정신과학교실 및 고려대학교안암병원 우울증 임상연구센터) ;
  • 이화영 (고려대학교 의과대학 안산병원 정신과학교실) ;
  • 백종우 (고려대학교 의과대학 안암병원 정신과학교실 및 고려대학교안암병원 우울증 임상연구센터) ;
  • 강이헌 (고려대학교 의과대학 안암병원 정신과학교실 및 고려대학교안암병원 우울증 임상연구센터) ;
  • 이민수 (고려대학교 의과대학 안암병원 정신과학교실 및 고려대학교안암병원 우울증 임상연구센터)
  • Published : 2006.08.31

Abstract

Objective : Since some studies have shown that the brain-derived neurotrophic factor(BDNF) has an important role in the pathophysiology of depression, this study investigated the relationship between BDNF genetic polymorphism and the long-term outcome of the antidepressant treatment. Method : One hundred and eight patients with major depressive disorder were evaluated for the long-term outcome(up to 3 years) of antidepressant treatment. The severity and improvement of depression were assessed with the Clinical Global Impression(CGI) Scale. The genotypes of BDNF 196A/G polymorphism in the patients were determined using Restriction Fragment Length Polymorphism(RFLP). Result : The genotypes of 128 patients were investigated and 95 patients of those have been evaluated for 3 years. No significant differences were noted comparing three-genotype groups for CGI scales at baseline, 4 weeks, 8 weeks, 1 year, 2 years and 3 years. Conclusion : This result shows that BDNF polymorphism investigated in this study was not associated with the long-term outcome of the antidepressant treatment. However, further studies with another BDNF polymorphism should be needed.

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