생물정신의학 (Korean Journal of Biological Psychiatry)
- 제13권3호
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- Pages.137-143
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- 2006
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
정신분열병과 P50
P50 and Schizophrenia
- Lee, Seung-Hwan (Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea) ;
- Seo, Hyung-Seok (Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea) ;
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Chung, Young-Cho
(Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea)
- 발행 : 2006.08.31
초록
One of the most widely recognized neurophysiologic endophenotypes for schizophrenia is deficient gating or inhibition of the P50 component of the auditory event-related potential(ERP). A deficit in P50 sensory gating refers to a dysfunction in the mechanism responsible for modulating the brain's sensitivity of filtering out irrelevant or background stimuli, perhaps as a result of dysfunction in inhibitory neural circuits. In this paper, we review the neuronal and genetic aspects as well as medication effects on P50 in schizophrenia.