생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제13권3호
  • /
  • Pages.137-143
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  • 2006
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
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정신분열병과 P50

P50 and Schizophrenia

  • 이승환 (인제대학교 의과대학 일산백병원 신경정신과학교실) ;
  • 서형석 (인제대학교 의과대학 일산백병원 신경정신과학교실) ;
  • 정영조 (인제대학교 의과대학 일산백병원 신경정신과학교실)
  • Lee, Seung-Hwan (Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea) ;
  • Seo, Hyung-Seok (Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea) ;
  • Chung, Young-Cho (Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea)
  • 발행 : 2006.08.31
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초록

One of the most widely recognized neurophysiologic endophenotypes for schizophrenia is deficient gating or inhibition of the P50 component of the auditory event-related potential(ERP). A deficit in P50 sensory gating refers to a dysfunction in the mechanism responsible for modulating the brain's sensitivity of filtering out irrelevant or background stimuli, perhaps as a result of dysfunction in inhibitory neural circuits. In this paper, we review the neuronal and genetic aspects as well as medication effects on P50 in schizophrenia.

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