Journal of Nutrition and Health

  • 제39권1호
  • /
  • Pages.11-17
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  • 2006
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

카제인포스포펩티드의 수준별 섭취가 난소절제 흰쥐의 골대사에 미치는 영향

Effect of Dietary Caseinphosphopeptide Levels on Bone Metabolism in Ovariectomized Rats

  • Yang Daum (Department of Food and Nutrition, Kookmin University) ;
  • Lee Jin-Woo (Department of Dentistry, Dankook University) ;
  • Park Hong Joo (Rural Resources Development Institute) ;
  • Kim Sun Hee (Department of Food and Nutrition, Kookmin University) ;
  • Chang Moon-Jeong (Department of Food and Nutrition, Kookmin University)
  • 발행 : 2006.01.01
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초록

The effect of the level of casein phosphopeptide (CPP) on mineral (Ca and P) bioavailabilties and bone biomarker of aged ovariectomized (OVX) Sprague-Dawley rats were studied as a model for postmenopausal bone loss. Forty five Spargue dawley rats, 220-230 g of body weight were fed a control diet (AIN 93M) or containing different level of CPP diet for 7 weeks: $0\%$ (sham control; SC, OVX control; OC), $1\%$ (OVX low CPP diet: OL), $2\%$ (OVX medium CPP diet; OM), $3\%$ (OVX high CPP diet; OH) Ca absorption was unaffected by increasing CPP content from 0 to $3\%$. Urinary Ca excretion was increased by OVX, and decreased by CPP significantly (p < 0.05) with no evident doserelationship. The urinary P excretion was increased by CPP intake in OVX rats. The fecal excretion of P given CPP decreased in OVX with dose dependent manner. Ca and P contents of femur significantly increased by adding 2 or $3\%$ of CPP when compared with OC group and OL group (p < 0.05). There were no significant differences in serum alkaline phosphatase activity and c-terminal telopeptide excretion in experimental groups. Although ovariectomy induced the increase in urinary c-terminal telopeptide excretion, 2 or $3\%$ of CPP in the diet decreased urinary c-terminal telopetide excretion significantly. These finding suggest the usefulness of CPP in the prevention of postmenopausal bone loss by decreasing urinary Ca excretion and bone resorption. Over 2 percent of CPP in the diet was effective to prevent postmenopausal bone loss.

키워드

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