Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
권호 표지

In vitro Activity of Sodium Benzoate Against Clinically Relevant Enterococcus faecalis and Enterococcus faecium Isolates

  • Karabay Oguz (Department of Infectious Diseases and Clinical Microbiology, Izzet Baysal Medical Faculty, Abant Izzet Baysal University) ;
  • Kocoglu Esra (Department of Microbiology and Clinical Microbiology, Izzet Baysal Medical Faculty, Abant Izzet Baysal University) ;
  • Ince Nevin (Department of Infectious Diseases and Clinical Microbiology, Izzet Baysal Medical Faculty, Abant Izzet Baysal University) ;
  • Sahan Tufan (Microbiology laboratory of Izzet Baysal Medical Faculty, Abant Izzet Baysal University) ;
  • Ozdemir Davut (Department of Infectious Diseases and Clinical Microbiology, Duzce Medical Faculty, Abant Izzet Baysal University)
  • Published : 2006.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

The antimicrobial effects of sodium benzoate against Enterococcus faecalis and Enterococcus faecium were investigated. The $MIC_{90}$ of sodium benzoate were 64 mg/ for E. faecalis and 32 mg/L for E. faecium, while the $MBC_{90}$ were 128 mg/L and 64mg/L, respectively. Although further studies are required for clinical evidence, sodium benzoate seems to be effective against Enterococcus spp.

Keywords

References

  1. Facklom, R.R. and D.F. Sahm. 1995. Enterococcus, p.308- 314. In Murray, P.R., Baron E.J.P., Foller M.A., Tenoxer, F.C. and R.H. Yolken. (eds). Manuel of Clinical Microbiology, ASM press, Washington
  2. Fridkin, S.K. and R.P. Gaynes. 1999. Antimicrobial resistance in intensive care units. Clinics in Chest Medicine 20, 303-316 https://doi.org/10.1016/S0272-5231(05)70143-X
  3. Gold, H.S. 2001. Vancomycin-resistant enterococci: mechanisms and clinical observations. Clinical Infectious Diseases 33, 210-219 https://doi.org/10.1086/321815
  4. Karabay, O. and I. Sahin. 2005. In vitro activity of sodium-benzoate against isolates of methicillin-resistant Staphylococcus aureus. West Indian Medical Journal 54, 119-121
  5. Killian, M. 2002. Streptococcus and enterococcus, p. 174-188. In Greenwood, D., Slack, R.C.B. and F.F. Peutherer (eds). Medical Microbiology, 16th ed. Churchill Livingstone, Philadelphia
  6. Lopez-Malo, A., A.S. Maris, and E. Palou. 2005. Aspergillus flavus growth in the presence of chemical preservatives and naturally occurring antimicrobial compounds. Int. J. Food Microbiol. 99, 119-128 https://doi.org/10.1016/j.ijfoodmicro.2004.08.010
  7. Murray, B.E. 1990. The life and times of enterococcus. Clinical Microbiology Reviews 3, 46-65 https://doi.org/10.1128/CMR.3.1.46
  8. National Committee for Clinical Laboratory Standards. 2003. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically-Fifth Edition: Approved Standard M7-A6. NCCLS, Villanova, PA, USA
  9. Robert, C. and J.R. Moellering. 2000. p. 2147-2153. Enterococcus species, Streptococcus bovis and Leuconostoc species. In Mandell, G.L., Bennett, J.E. and R. Dolin (eds). Principles and practice of infectious diseases. 5th ed. Churchill Livingstone, Philadelphia
  10. Takeda, E., Y. Kuroda, K. Toshima, T. Watanabe, E. Naito and M. Miyao. 1983. Effect of long-term administration of sodium benzoate to a patient with partial ornithine carbamoyl transferase deficiency. Clin. Pediatr. (Phila) 22, 206-208 https://doi.org/10.1177/000992288302200309