Anticancer Effects of 23-Dihydroganoderic Acid N

  • Kang Kyoung-Ah (Department of Biochemistry College of Medicine, Cheju National University) ;
  • Zhang Rui (Department of Biochemistry College of Medicine, Cheju National University) ;
  • Piao Mei Jing (Department of Biochemistry College of Medicine, Cheju National University) ;
  • Kim Ju-Sun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kang Sam-Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Hyun Jin-Won (Department of Biochemistry College of Medicine, Cheju National University)
  • 발행 : 2006.12.31

초록

23-Dihydroganoderic acid N, a triterpenoid compound, was investigated whether it may show cytotoxic activity against U937, HeLa, NCI-H460 and MCF-7 cancer cells by MTT test. As a result, 23-dihydroganoderic acid N show sensitive to MCF-7 cells among NCI-H460, HeLa, U937, and MCF-7 cells.

키워드

참고문헌

  1. Bao, X.F., Wang, X.S., Dong, Q., Fang, J.N. and Li, X.Y. (2002) Structural features of immunologically active polysaccharides from Ganoderma lucidum. Phytochem., 59, 175-181 https://doi.org/10.1016/S0031-9422(01)00450-2
  2. Carmichael, J., DeGraff, W.G., Gazdar, A.F., Minna, J.D. and Mitchell, J.B. (1987): Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer. Res., 47, 936-941
  3. Hong, K.J., Dunn, D.M., Shen, C.L. and Pence, B.C. (2004) Effects of Ganoderma lucidum on apoptotic and antiinflammatory function in HT-29 human colonic carcinoma cells. Phytother.Res., 18, 768-770 https://doi.org/10.1002/ptr.1495
  4. Kohda, H., Tokumoto, W., Sakamoto, K., Fuji, M., Hirai, Y., Yamasaki, K., Komoda, Y., Nakamura, H., Ishihara, S. and Uchida, M. (1985) The biologically active constituents of Ganoderma lucidum (Fr.) Karst, Histamine release-inhibitory triterpenes. Chem. Pharm. Bull., 33, 1367-1374 https://doi.org/10.1248/cpb.33.1367
  5. Komoda, Y., Shimizu, M., Sonoda, Y. and Sato, Y. (1989) Ganoderic acid and its derivatives as cholesterol synthesis inhibitors. Chem. Pharm. Bull., 37, 531-533 https://doi.org/10.1248/cpb.37.531
  6. Min, B.S., Gao, J.J., Hattori, M., Lei, H.K. and Kim, Y.H. (2001) Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med., 67, 811-814 https://doi.org/10.1055/s-2001-18854
  7. Min, B.S., Gao, J.J., Nakamura, N. and Hattori, M. (2000) Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem. Pharm. Bull., 48, 1026-1033 https://doi.org/10.1248/cpb.48.1026
  8. Min, B.S., Nakamura, N. and Hattori, M. (1998) Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem. Pharm. Bull., 46, 1607-1612 https://doi.org/10.1248/cpb.46.1607
  9. Mizuno, T., Wang, G., Zhang, J., Kawagishi, H., Nishitoba, T. and Li, J. (1995) Reishi, Ganoderma lucidum and Ganoderma tsugae: bioactive substances and medicinal effects. Food Rev. Int., 11, 151-166 https://doi.org/10.1080/87559129509541025