Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Present status and prospects of Haemophilus influenzae type b(Hib) immunization

Haemophilus influenzae type b(Hib) 백신 접종의 현황과 전망

  • Kim, Kyung Hyo (Department of Pediatrics, College of Medicine, Ewha Woman's University)
  • 김경효 (이화여자대학교 의과대학 소아과학교실)
  • Received : 2006.02.08
  • Accepted : 2006.02.10
  • Published : 2006.03.15
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Abstract

Haemophilus influenzae type b(Hib) conjugate vaccines prevent Hib disease in individuals and reduce the carriage and transmission of the organism in the community. The incidence of Hib disease has been decreased dramatically in a diverse range of countries through the use of a variety of conjugate vaccines and vaccine schedules. In some countries, the vaccine has caused a near-disappearance of invasive Hib disease through a combination of direct protection and herd immunity. The effectiveness of the vaccine was not modified by the type of conjugate vaccine, the number of doses given(two, three or four), age at first vaccination(two months, 42 to 90 days, three months) and whether the vaccine was tested in an industrialized or developing country. Over 15 years of international experience with vaccines has also demonstrated that they are safe. In 2004, Hib vaccines were adapted in routine immunization in 92 countries in the world. Decisions regarding the use of the Hib vaccine in routine immunization schedules depend not only on the effectiveness and efficacy of the vaccine but also on factors such as burden of disease, vaccine cost, and competing priorities. In Korea, Hib disease burden seemed to be lower than other developed countries(~10/100,000). Moreover Hib vaccines showed excellent immunogenicity in Korean children in many studies. Therefore, a potential approach to economize the cost of Hib vaccines could be to explore the possibilities of using reduced vaccine doses for immunization as some other countries.

Keywords

References

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