Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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The Wound Healing Effects of Alginate- crosslinked Collagen Dermal Substitute of Artificial Skin

콜라겐을 알긴산으로 교차 결합시킨 인공진피의 창상치유 효과

  • Chang, Jae Hoon (Department of Plastic and Reconstructive Surgery, Daegu Catholic University) ;
  • Park, Dae Hwan (Department of Plastic and Reconstructive Surgery, Daegu Catholic University) ;
  • Shin, Jeong Im (School of Medicine & Tissue Engineering Center, Daegu Catholic University) ;
  • Ahn, Ki Young (Department of Plastic and Reconstructive Surgery, Daegu Catholic University) ;
  • Song, Chul Hong (Department of Plastic and Reconstructive Surgery, Daegu Catholic University)
  • 장재훈 (대구가톨릭의과대학 성형외과학교실) ;
  • 박대환 (대구가톨릭의과대학 성형외과학교실) ;
  • 신정임 (대구가톨릭의과대학 조직공학센터) ;
  • 안기영 (대구가톨릭의과대학 성형외과학교실) ;
  • 송철홍 (대구가톨릭의과대학 성형외과학교실)
  • Received : 2005.07.29
  • Published : 2006.01.10
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Abstract

Alginate, which is isolated from brown seaweed, is a bioabsorbable long chain polysaccharides, ${\beta}$-D-mannuronic acid and ${\alpha}$-L-guluronic acid. The authors produced alginates and alginate-colllagen as a disc form. Then, to evaluate the efficacy of alginate and alginate-collagen complex as a wound healing material, three full-thickness skin defects of 2 cm in diameter were made at the back of the New Zealand white rabbits. Three groups of dressing materials-alginate, alginate-collagen complex and vaseline gauze as control group - were applied on the wound and the results were evaluated grossly and histopathologically. The authors compared gross findings of sizes of healed wound, wound epithelization and wound contraction by tracing the remaining wound area at 5th, 10th, 15th, 20th, 25th day after wound introduction, and wound biopsy was performed at 3rd, 7th, 14th, 21st day, respectively. Alginate and alginate-collagen complex showed statistically higher percentage of wound contraction and wound healing compared to control group(p<0.05). Alginate-collagen complex showed statistically higher percentage of wound contraction, epithelization and wound healing compared to alginate alone. In conclusion, the result suggests that alginate has a good effect of wound healing and that alginate-collagen complex is more effective in wound healing than alginate alone.

Keywords

Acknowledgement

Supported by : 대구가톨릭대학교

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