대한수의학회지 (Korean Journal of Veterinary Research)

  • 제46권1호
  • /
  • Pages.71-73
  • /
  • 2006
  • /
  • 2466-1384(pISSN)
  • /
  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지

Juvenile onset acquired myasthenia gravis in a Shih-tzu dog

  • 심사 : 2006.01.27
  • 발행 : 2006.03.29
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

A 7-month-old female Shih-tzu dog was presented with intermittent trembling, dyspnea, generalized muscle weakness, and unconsciousness after exercise. No remarkable findings were shown in the complete blood counts and the radiographic examination. On serum biochemical profiles, alkaline phosphatase and creatine phosphokinase were mildly elevated. Based on history takings, physical examination, and neurological findings, presumptive diagnosis was made as a myasthenia gravis (MG). Clinical signs of this patient were dramatically improved after administration of neostigmine. The result of acetylcholine receptor antibody test in serum was 0.89 nmol/L and the histopathology of muscle were normal. Clinical sign of the patient evaluated in this study is stabilized with long-term administration of pyridostigmine at this time. This case report here describes clinical and clinicopathological findings of a juvenile onset acquired MG in a Shih-tzu dog.

키워드

참고문헌

  1. Dewey CW, Bailey CS, Shelton GD, Kass P H, Cardinet GH. Clinical forms of acquired myasthenia gravis in dogs: 25 cases (1988-1995). J Vet Intern Med 1997, 11, 50-57 https://doi.org/10.1111/j.1939-1676.1997.tb00073.x
  2. Dewey CW, Coates JR, Ducote JM, Meeks JC, Fradkin JM. Azathioprine therapy for acquired myasthenia gravis in five dogs. J Am Anim Hosp Assoc 1999, 35, 396-402 https://doi.org/10.5326/15473317-35-5-396
  3. Ettinger SJ, Feldman EC. Peripheral nerve disorders. In: Ettinger SJ, Feldman EC (eds.). Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. 5th ed. pp. 675-676, Saunders, Philadelphia, 2000
  4. Flagstad A, Trojaborg W, Gammeltoft S. Congenital myasthenic syndrome in the dog breed Gammel Dansk, Honsehund: clinical, electrophysiological, pharmacological and immunological comparison with acquired myasthenia gravis. Acta Vet Scand 1989, 30, 89-102
  5. Indrieri RJ, Creighton SR, Lambert EH, Lennon VA. Myasthenia gravis in two cats. J Am Vet Med Assoc 1983, 182, 57-60
  6. King LG, Vite CH. Acute fulminating myasthenia gravis in five dogs. J Am Vet Med Assoc 1998, 212, 830-834
  7. Klebanow ER. Thymoma and acquired myasthenia gravis in the dog: a case report and review of 13 additional cases. J Am Anim Hosp Assoc 1992, 28, 63-69
  8. Lipsitz D, Berry JL, Shelton GD. Inherited predisposition to myasthenia gravis in Newfoundlands. J Am Vet Med Assoc 1999, 215, 956-958, 946
  9. Lorenz MD, DeLahunta A, Alstrom DH. Neostigmine responsive weakness in the dog, similar to myasthenia gravis. J Am Vet Med Assoc 1972, 161, 795-800
  10. Miller LM, Hegreberg GA, Prieur DJ, Hamilton MJ. Inheritance of congenital myasthenia gravis in smooth fox terrier dogs. J Hered 1984, 75, 163-166 https://doi.org/10.1093/oxfordjournals.jhered.a109904
  11. Miller LM, Lennon VA, Lambert EH, Reed SM, Hegreberg GA, Miller JB, Ott RL. Congenital myasthenia gravis in 13 smooth fox terriers. J Am Vet Med Assoc 1983, 182, 694-697
  12. Ormrod AN. Myasthenia gravis in a cocker spaniel. Vet Rec 1961, 73, 489-490
  13. Palmer AC. Myasthenia gravis. Vet Clin North Am Small Anim Pract 1980, 10, 213-221 https://doi.org/10.1016/S0195-5616(80)50012-4
  14. Pendens J. Junctionopathies: Disorders of the neuromuscular junction. In: Dewey CW (ed.). A Practical Guide to Canine and Feline Neurology. 1st ed. pp. 467-488, Iowa State Press, Ames, 2003
  15. Shelton GD, Schule A, Kass PH. Risk factors for acquired myasthenia gravis in dogs: 1,154 cases (1991-1995). J Am Vet Med Assoc 1997, 211, 1428-1431
  16. Shelton GD, Willard MD, Cardinet GH 3rd, Lindstrom J. Acquired myasthenia gravis. Selective involvement of esophageal, pharyngeal, and facial muscles. J Vet Intern Med 1990, 4, 281-284 https://doi.org/10.1111/j.1939-1676.1990.tb03124.x
  17. Uchida K, Awamura Y, Nakamura T, Yamaguchi R, Tateyamas. Thymoma and multiple thymic cysts in a dog with acquired myasthenia gravis. J Vet Med Sci 2002, 64, 637-640 https://doi.org/10.1292/jvms.64.637